Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

Using single-cell RNA sequencing, Dong, Miao, Wang et al. profile the transcriptomes of 21,292 cells from biopsies of 6 castration-resistant prostate cancers. They find that all neuroendocrine tumor cells display a luminal-like epithelial phenotype, providing insights into the cellular states underl...

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Autores principales: Baijun Dong, Juju Miao, Yanqing Wang, Wenqin Luo, Zhongzhong Ji, Huadong Lai, Man Zhang, Xiaomu Cheng, Jinming Wang, Yuxiang Fang, Helen He Zhu, Chee Wai Chua, Liancheng Fan, Yinjie Zhu, Jiahua Pan, Jia Wang, Wei Xue, Wei-Qiang Gao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/d4789977decd4a4196f4b021074be091
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Sumario:Using single-cell RNA sequencing, Dong, Miao, Wang et al. profile the transcriptomes of 21,292 cells from biopsies of 6 castration-resistant prostate cancers. They find that all neuroendocrine tumor cells display a luminal-like epithelial phenotype, providing insights into the cellular states underlying neuroendocrine transdifferentiation in human prostate cancer.

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