Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer
Using single-cell RNA sequencing, Dong, Miao, Wang et al. profile the transcriptomes of 21,292 cells from biopsies of 6 castration-resistant prostate cancers. They find that all neuroendocrine tumor cells display a luminal-like epithelial phenotype, providing insights into the cellular states underl...
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/d4789977decd4a4196f4b021074be091 |
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oai:doaj.org-article:d4789977decd4a4196f4b021074be0912021-12-02T13:33:58ZSingle-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer10.1038/s42003-020-01476-12399-3642https://doaj.org/article/d4789977decd4a4196f4b021074be0912020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01476-1https://doaj.org/toc/2399-3642Using single-cell RNA sequencing, Dong, Miao, Wang et al. profile the transcriptomes of 21,292 cells from biopsies of 6 castration-resistant prostate cancers. They find that all neuroendocrine tumor cells display a luminal-like epithelial phenotype, providing insights into the cellular states underlying neuroendocrine transdifferentiation in human prostate cancer.Baijun DongJuju MiaoYanqing WangWenqin LuoZhongzhong JiHuadong LaiMan ZhangXiaomu ChengJinming WangYuxiang FangHelen He ZhuChee Wai ChuaLiancheng FanYinjie ZhuJiahua PanJia WangWei XueWei-Qiang GaoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Baijun Dong Juju Miao Yanqing Wang Wenqin Luo Zhongzhong Ji Huadong Lai Man Zhang Xiaomu Cheng Jinming Wang Yuxiang Fang Helen He Zhu Chee Wai Chua Liancheng Fan Yinjie Zhu Jiahua Pan Jia Wang Wei Xue Wei-Qiang Gao Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer |
| description |
Using single-cell RNA sequencing, Dong, Miao, Wang et al. profile the transcriptomes of 21,292 cells from biopsies of 6 castration-resistant prostate cancers. They find that all neuroendocrine tumor cells display a luminal-like epithelial phenotype, providing insights into the cellular states underlying neuroendocrine transdifferentiation in human prostate cancer. |
| format |
article |
| author |
Baijun Dong Juju Miao Yanqing Wang Wenqin Luo Zhongzhong Ji Huadong Lai Man Zhang Xiaomu Cheng Jinming Wang Yuxiang Fang Helen He Zhu Chee Wai Chua Liancheng Fan Yinjie Zhu Jiahua Pan Jia Wang Wei Xue Wei-Qiang Gao |
| author_facet |
Baijun Dong Juju Miao Yanqing Wang Wenqin Luo Zhongzhong Ji Huadong Lai Man Zhang Xiaomu Cheng Jinming Wang Yuxiang Fang Helen He Zhu Chee Wai Chua Liancheng Fan Yinjie Zhu Jiahua Pan Jia Wang Wei Xue Wei-Qiang Gao |
| author_sort |
Baijun Dong |
| title |
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer |
| title_short |
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer |
| title_full |
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer |
| title_fullStr |
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer |
| title_full_unstemmed |
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer |
| title_sort |
single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/d4789977decd4a4196f4b021074be091 |
| work_keys_str_mv |
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1718392823761338368 |