Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance

Rahnuma Ahmad,1 Qazi Shamima Akhter,2 Mainul Haque3 1Department of Physiology, Medical College for Women and Hospital, Dhaka, Bangladesh; 2Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh; 3The Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ahmad R, Akhter QS, Haque M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cement dust occupational health inflammatory response hazard workers exposure wbc count biomarkers bangladesh pollution hematological system early detection Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d47a3553ad9a44088594fbde430cc199
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d47a3553ad9a44088594fbde430cc199
record_format	dspace
spelling	oai:doaj.org-article:d47a3553ad9a44088594fbde430cc1992021-12-02T17:37:19ZOccupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance1178-7031https://doaj.org/article/d47a3553ad9a44088594fbde430cc1992021-06-01T00:00:00Zhttps://www.dovepress.com/occupational-cement-dust-exposure-and-inflammatory-nemesis-bangladesh--peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Rahnuma Ahmad,1 Qazi Shamima Akhter,2 Mainul Haque3 1Department of Physiology, Medical College for Women and Hospital, Dhaka, Bangladesh; 2Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh; 3The Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, 57000, Kuala Lumpur, MalaysiaCorrespondence: Mainul HaqueThe Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, Kuala Lumpur, 57000, MalaysiaTel +60109265543Email runurono@gmail.comBackground: Prolonged, repeated exposure to cement dust, depending on duration and sensitivity of cement dust-exposed workers, may cause deteriorating effects on the skin, eye, respiratory and hematological system. Toxic cement dust causes inflammatory damage to different body organs. White blood cells (WBCs) are considered cellular markers of ongoing tissue inflammation.Aim of the Study: Determining the influence of occupational cement dust exposure on WBCs with its differentials (inflammatory markers) in workers from the cement manufacturing plant.Methodology: Ninety-two seemingly healthy male subjects (46 workers of cement plant and 46 control subjects, who do not contact cement dust, residing in Dhaka) aged between 20 and 50 years participated in this cross-sectional study. This study took place in Dhaka Medical College, Bangladesh, between the years of 2017 and 2018. An automated hematoanalyser was used to assess both the total and differential count of WBC. Data were analyzed with multivariate regression analysis, independent samples t-test, and correlation test.Results: The total WBC count, differential count of lymphocyte, and eosinophil were significantly (p< 0.05) higher in cement dust-exposed recruits than in the control group. Additionally, multivariate regression analysis revealed that duration of cement dust exposure showed a significant association with total WBC count [odds ratio (OR)=4.42,95%, confidence level (CI) 1.56,12.47, p 0.005]. Furthermore, univariate analysis revealed that the control group (not exposed to cement dust) was less likely to have the total WBC count alteration (OR = 0.122, 95% CI =0.047 to 0.311) than the cement dust-exposed group. The total WBC count showed a significant positive correlation with exposure duration to this toxic dust.Conclusion: Cement dust exposure causes harmful inflammatory responses, as evidenced by increased total and differential WBC count. The period of contact with this toxic dust has an impact on WBC count.Keywords: cement dust, occupational health, inflammatory response, hazard, workers, exposure, WBC count, biomarkers, Bangladesh, pollution, hematological system, early detectionAhmad RAkhter QSHaque MDove Medical Pressarticlecement dustoccupational healthinflammatory responsehazardworkersexposurewbc countbiomarkersbangladeshpollutionhematological systemearly detectionPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 2425-2444 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cement dust occupational health inflammatory response hazard workers exposure wbc count biomarkers bangladesh pollution hematological system early detection Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	cement dust occupational health inflammatory response hazard workers exposure wbc count biomarkers bangladesh pollution hematological system early detection Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Ahmad R Akhter QS Haque M Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance
description	Rahnuma Ahmad,1 Qazi Shamima Akhter,2 Mainul Haque3 1Department of Physiology, Medical College for Women and Hospital, Dhaka, Bangladesh; 2Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh; 3The Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, 57000, Kuala Lumpur, MalaysiaCorrespondence: Mainul HaqueThe Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, Kuala Lumpur, 57000, MalaysiaTel +60109265543Email runurono@gmail.comBackground: Prolonged, repeated exposure to cement dust, depending on duration and sensitivity of cement dust-exposed workers, may cause deteriorating effects on the skin, eye, respiratory and hematological system. Toxic cement dust causes inflammatory damage to different body organs. White blood cells (WBCs) are considered cellular markers of ongoing tissue inflammation.Aim of the Study: Determining the influence of occupational cement dust exposure on WBCs with its differentials (inflammatory markers) in workers from the cement manufacturing plant.Methodology: Ninety-two seemingly healthy male subjects (46 workers of cement plant and 46 control subjects, who do not contact cement dust, residing in Dhaka) aged between 20 and 50 years participated in this cross-sectional study. This study took place in Dhaka Medical College, Bangladesh, between the years of 2017 and 2018. An automated hematoanalyser was used to assess both the total and differential count of WBC. Data were analyzed with multivariate regression analysis, independent samples t-test, and correlation test.Results: The total WBC count, differential count of lymphocyte, and eosinophil were significantly (p< 0.05) higher in cement dust-exposed recruits than in the control group. Additionally, multivariate regression analysis revealed that duration of cement dust exposure showed a significant association with total WBC count [odds ratio (OR)=4.42,95%, confidence level (CI) 1.56,12.47, p 0.005]. Furthermore, univariate analysis revealed that the control group (not exposed to cement dust) was less likely to have the total WBC count alteration (OR = 0.122, 95% CI =0.047 to 0.311) than the cement dust-exposed group. The total WBC count showed a significant positive correlation with exposure duration to this toxic dust.Conclusion: Cement dust exposure causes harmful inflammatory responses, as evidenced by increased total and differential WBC count. The period of contact with this toxic dust has an impact on WBC count.Keywords: cement dust, occupational health, inflammatory response, hazard, workers, exposure, WBC count, biomarkers, Bangladesh, pollution, hematological system, early detection
format	article
author	Ahmad R Akhter QS Haque M
author_facet	Ahmad R Akhter QS Haque M
author_sort	Ahmad R
title	Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance
title_short	Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance
title_full	Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance
title_fullStr	Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance
title_full_unstemmed	Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance
title_sort	occupational cement dust exposure and inflammatory nemesis: bangladesh relevance
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d47a3553ad9a44088594fbde430cc199
work_keys_str_mv	AT ahmadr occupationalcementdustexposureandinflammatorynemesisbangladeshrelevance AT akhterqs occupationalcementdustexposureandinflammatorynemesisbangladeshrelevance AT haquem occupationalcementdustexposureandinflammatorynemesisbangladeshrelevance
_version_	1718379911403536384

Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance

Ejemplares similares