Role of microRNAs in COVID-19 with implications for therapeutics

COVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects both animals and humans. Although many efforts are currently underway to test possible therapies, there is no specific FDA ap...

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Autores principales:	Nahid Arghiani, Tracy Nissan, Maryam M. Matin
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	SARS-CoV-2 Coronavirus miRNAs Anti-miRNA therapy miRNA therapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d47eec6e45f546f09cd2a809deb6b9a5
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id	oai:doaj.org-article:d47eec6e45f546f09cd2a809deb6b9a5
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spelling	oai:doaj.org-article:d47eec6e45f546f09cd2a809deb6b9a52021-11-14T04:28:49ZRole of microRNAs in COVID-19 with implications for therapeutics0753-332210.1016/j.biopha.2021.112247https://doaj.org/article/d47eec6e45f546f09cd2a809deb6b9a52021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010313https://doaj.org/toc/0753-3322COVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects both animals and humans. Although many efforts are currently underway to test possible therapies, there is no specific FDA approved drug against SARS-CoV-2 yet. miRNA-directed gene regulation controls the majority of biological processes. In addition, the development and progression of several human diseases are associated with dysregulation of miRNAs. In this regard, it has been shown that changes in miRNAs are linked to severity of COVID-19 especially in patients with respiratory diseases, diabetes, heart failure or kidney problems. Therefore, targeting these small noncoding-RNAs could potentially alleviate complications from COVID-19. Here, we will review the roles and importance of host and RNA virus encoded miRNAs in COVID-19 pathogenicity and immune response. Then, we focus on potential miRNA therapeutics in the patients who are at increased risk for severe disease.Nahid ArghianiTracy NissanMaryam M. MatinElsevierarticleSARS-CoV-2CoronavirusmiRNAsAnti-miRNA therapymiRNA therapyTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112247- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 Coronavirus miRNAs Anti-miRNA therapy miRNA therapy Therapeutics. Pharmacology RM1-950
spellingShingle	SARS-CoV-2 Coronavirus miRNAs Anti-miRNA therapy miRNA therapy Therapeutics. Pharmacology RM1-950 Nahid Arghiani Tracy Nissan Maryam M. Matin Role of microRNAs in COVID-19 with implications for therapeutics
description	COVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects both animals and humans. Although many efforts are currently underway to test possible therapies, there is no specific FDA approved drug against SARS-CoV-2 yet. miRNA-directed gene regulation controls the majority of biological processes. In addition, the development and progression of several human diseases are associated with dysregulation of miRNAs. In this regard, it has been shown that changes in miRNAs are linked to severity of COVID-19 especially in patients with respiratory diseases, diabetes, heart failure or kidney problems. Therefore, targeting these small noncoding-RNAs could potentially alleviate complications from COVID-19. Here, we will review the roles and importance of host and RNA virus encoded miRNAs in COVID-19 pathogenicity and immune response. Then, we focus on potential miRNA therapeutics in the patients who are at increased risk for severe disease.
format	article
author	Nahid Arghiani Tracy Nissan Maryam M. Matin
author_facet	Nahid Arghiani Tracy Nissan Maryam M. Matin
author_sort	Nahid Arghiani
title	Role of microRNAs in COVID-19 with implications for therapeutics
title_short	Role of microRNAs in COVID-19 with implications for therapeutics
title_full	Role of microRNAs in COVID-19 with implications for therapeutics
title_fullStr	Role of microRNAs in COVID-19 with implications for therapeutics
title_full_unstemmed	Role of microRNAs in COVID-19 with implications for therapeutics
title_sort	role of micrornas in covid-19 with implications for therapeutics
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d47eec6e45f546f09cd2a809deb6b9a5
work_keys_str_mv	AT nahidarghiani roleofmicrornasincovid19withimplicationsfortherapeutics AT tracynissan roleofmicrornasincovid19withimplicationsfortherapeutics AT maryammmatin roleofmicrornasincovid19withimplicationsfortherapeutics
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Role of microRNAs in COVID-19 with implications for therapeutics

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