Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity

Xianglong Ding,1 Xiaoqin Yang,2 Lei Zhou,1 Haibin Lu,1 Shaobing Li,1 Yan Gao,1 Chunhua Lai,1 Ying Jiang11Center of Oral Implantology, 2Department of Oral and Maxillofacial Surgery, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, People&#39;s Republic of...

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Autores principales:	Ding XL, Yang XQ, Zhou L, Lu HB, Li SB, Gao Y, Lai CH, Jiang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d47fe833ba4343d1af81ca63ef899fbd
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spelling	oai:doaj.org-article:d47fe833ba4343d1af81ca63ef899fbd2021-12-02T07:37:01ZTitanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity1176-91141178-2013https://doaj.org/article/d47fe833ba4343d1af81ca63ef899fbd2013-02-01T00:00:00Zhttp://www.dovepress.com/titanate-nanowire-scaffolds-decorated-with-anatase-nanocrystals-show-g-a12143https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Xianglong Ding,1 Xiaoqin Yang,2 Lei Zhou,1 Haibin Lu,1 Shaobing Li,1 Yan Gao,1 Chunhua Lai,1 Ying Jiang11Center of Oral Implantology, 2Department of Oral and Maxillofacial Surgery, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, People&#39;s Republic of ChinaBackground and methods: In this report, layered microporous titanate nanowire scaffolds (TiNWs) were constructed via a hydrothermal route and then decorated with anatase nanocrystals (ANs@TiNWs) by immersion in TiCl4 solution. The diameter and specific surface area of the ANs@TiNWs was measured. The TiNWs and ANs@TiNWs were then compared for their ability to adsorb protein and adhere to MG63 cells.Results: The diameter and specific surface area of the ANs@TiNWs were significantly larger than for TiNWs, and the ANs@TiNWs had an enhanced protein-adsorbing effect. It was found that the MG63 cells were less able to adhere to the flat titanium substrate than the TiNWs and ANs@TiNWs, and that this cell-repellant ability was greater with ANs@TiNWs. Other MG63 cell functions, proliferation in particular, were also inhibited by ANs@TiNWs.Conclusion: ANs@TiNWs show a high protein adsorption and cell-repellant capacity which would be useful in drug delivery.Keywords: protein adsorption, antiadhesion, nanotopography, drug deliveryDing XLYang XQZhou LLu HBLi SBGao YLai CHJiang YDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 569-579 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ding XL Yang XQ Zhou L Lu HB Li SB Gao Y Lai CH Jiang Y Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity
description	Xianglong Ding,1 Xiaoqin Yang,2 Lei Zhou,1 Haibin Lu,1 Shaobing Li,1 Yan Gao,1 Chunhua Lai,1 Ying Jiang11Center of Oral Implantology, 2Department of Oral and Maxillofacial Surgery, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, People&#39;s Republic of ChinaBackground and methods: In this report, layered microporous titanate nanowire scaffolds (TiNWs) were constructed via a hydrothermal route and then decorated with anatase nanocrystals (ANs@TiNWs) by immersion in TiCl4 solution. The diameter and specific surface area of the ANs@TiNWs was measured. The TiNWs and ANs@TiNWs were then compared for their ability to adsorb protein and adhere to MG63 cells.Results: The diameter and specific surface area of the ANs@TiNWs were significantly larger than for TiNWs, and the ANs@TiNWs had an enhanced protein-adsorbing effect. It was found that the MG63 cells were less able to adhere to the flat titanium substrate than the TiNWs and ANs@TiNWs, and that this cell-repellant ability was greater with ANs@TiNWs. Other MG63 cell functions, proliferation in particular, were also inhibited by ANs@TiNWs.Conclusion: ANs@TiNWs show a high protein adsorption and cell-repellant capacity which would be useful in drug delivery.Keywords: protein adsorption, antiadhesion, nanotopography, drug delivery
format	article
author	Ding XL Yang XQ Zhou L Lu HB Li SB Gao Y Lai CH Jiang Y
author_facet	Ding XL Yang XQ Zhou L Lu HB Li SB Gao Y Lai CH Jiang Y
author_sort	Ding XL
title	Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity
title_short	Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity
title_full	Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity
title_fullStr	Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity
title_full_unstemmed	Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity
title_sort	titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d47fe833ba4343d1af81ca63ef899fbd
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Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity

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