PACAP suppresses dry eye signs by stimulating tear secretion

Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.

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Auteurs principaux:	Tomoya Nakamachi, Hirokazu Ohtaki, Tamotsu Seki, Sachiko Yofu, Nobuyuki Kagami, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Laszlo Mark, Ingela Lanekoff, Peter Kiss, Jozsef Farkas, Dora Reglodi, Seiji Shioda
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/d48095ef948f429dba72a08d3786bfe1
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spelling	oai:doaj.org-article:d48095ef948f429dba72a08d3786bfe12021-12-02T17:33:20ZPACAP suppresses dry eye signs by stimulating tear secretion10.1038/ncomms120342041-1723https://doaj.org/article/d48095ef948f429dba72a08d3786bfe12016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12034https://doaj.org/toc/2041-1723Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.Tomoya NakamachiHirokazu OhtakiTamotsu SekiSachiko YofuNobuyuki KagamiHitoshi HashimotoNorihito ShintaniAkemichi BabaLaszlo MarkIngela LanekoffPeter KissJozsef FarkasDora ReglodiSeiji ShiodaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomoya Nakamachi Hirokazu Ohtaki Tamotsu Seki Sachiko Yofu Nobuyuki Kagami Hitoshi Hashimoto Norihito Shintani Akemichi Baba Laszlo Mark Ingela Lanekoff Peter Kiss Jozsef Farkas Dora Reglodi Seiji Shioda PACAP suppresses dry eye signs by stimulating tear secretion
description	Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.
format	article
author	Tomoya Nakamachi Hirokazu Ohtaki Tamotsu Seki Sachiko Yofu Nobuyuki Kagami Hitoshi Hashimoto Norihito Shintani Akemichi Baba Laszlo Mark Ingela Lanekoff Peter Kiss Jozsef Farkas Dora Reglodi Seiji Shioda
author_facet	Tomoya Nakamachi Hirokazu Ohtaki Tamotsu Seki Sachiko Yofu Nobuyuki Kagami Hitoshi Hashimoto Norihito Shintani Akemichi Baba Laszlo Mark Ingela Lanekoff Peter Kiss Jozsef Farkas Dora Reglodi Seiji Shioda
author_sort	Tomoya Nakamachi
title	PACAP suppresses dry eye signs by stimulating tear secretion
title_short	PACAP suppresses dry eye signs by stimulating tear secretion
title_full	PACAP suppresses dry eye signs by stimulating tear secretion
title_fullStr	PACAP suppresses dry eye signs by stimulating tear secretion
title_full_unstemmed	PACAP suppresses dry eye signs by stimulating tear secretion
title_sort	pacap suppresses dry eye signs by stimulating tear secretion
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d48095ef948f429dba72a08d3786bfe1
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PACAP suppresses dry eye signs by stimulating tear secretion

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