PACAP suppresses dry eye signs by stimulating tear secretion

PACAP suppresses dry eye signs by stimulating tear secretion

Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.

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Bibliographic Details
Main Authors: Tomoya Nakamachi, Hirokazu Ohtaki, Tamotsu Seki, Sachiko Yofu, Nobuyuki Kagami, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Laszlo Mark, Ingela Lanekoff, Peter Kiss, Jozsef Farkas, Dora Reglodi, Seiji Shioda
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/d48095ef948f429dba72a08d3786bfe1
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Internet

https://doaj.org/article/d48095ef948f429dba72a08d3786bfe1

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