Phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi

Solanum anguivi Lam. is an ethnomedicinal plant. Local traditional practitioners believe that it reduces the risk of diabetes and atherosclerosis diseases. The present study was intended to conduct qualitative phytochemical analysis, determine the total flavonoid and phenolic contents, estimate the...

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Autores principales:	Misganaw Tegegne, Enkuahone Abiyu, Solomon Libesu, Belete Bedemo, Mekuanint Lewoyehu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	solanum anguivi phytochemical antioxidant activity antibacterial activity total phenol and total flavonoid contents Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/d483a0674d7a4da9be992cc6452552e1
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spelling	oai:doaj.org-article:d483a0674d7a4da9be992cc6452552e12021-11-04T15:00:41ZPhytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi1310-28181314-353010.1080/13102818.2021.1993087https://doaj.org/article/d483a0674d7a4da9be992cc6452552e12021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13102818.2021.1993087https://doaj.org/toc/1310-2818https://doaj.org/toc/1314-3530Solanum anguivi Lam. is an ethnomedicinal plant. Local traditional practitioners believe that it reduces the risk of diabetes and atherosclerosis diseases. The present study was intended to conduct qualitative phytochemical analysis, determine the total flavonoid and phenolic contents, estimate the antioxidant capacity and antibacterial activities of the extracts of the fruits of this plant. The antioxidant activity was determined by analyzing the radical scavenging activity (RSA) using 2,2-diphenyl-1-picryhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) assays. The antibacterial activities were determined by the agar well diffusion method. Qualitative phytochemical screening of the crude extracts obtained from the fruits of the plant indicated the presence of alkaloids, flavonoids, phenols, glycosides, steroids, terpenoids, saponins and tannins. The highest total phenolic and total flavonoid content were obtained in the ethanol extract of the fruits, followed by dichloromethane and n-hexane extract. The total phenolic content (in gallic acid equivalents, GAE) ranged from 113.3 to 202.72 mg GAE/g. The total flavonoid content (in catechin equivalent, CE) varied from 61.72 to 142.64 mg (CE)/g. All fruit extracts of S. anguivi exhibited antioxidant activity as revealed by DPPH and FRAP assays. The DPPH RSA (% inhibition) of the fruit extract varied from 35.11 to 80.13. The total phenolic and Flavonoid contents showed alinear correlation with RSA. Furthermore, all fruit extracts showed antibacterial activity against gram-positive and gram-negative bacteria varying from 12.5 to 16.75 mm. The result showed that the extracts of the plant exerted stronger bactericidal effect on gram-positive bacteria than on gram-negative bacteria. Supplemental data for this article is available online at https://doi.org/10.1080/13102818.2021.1993087 .Misganaw TegegneEnkuahone AbiyuSolomon LibesuBelete BedemoMekuanint LewoyehuTaylor & Francis Grouparticle solanum anguivi phytochemicalantioxidant activityantibacterial activitytotal phenol and total flavonoid contentsBiotechnologyTP248.13-248.65ENBiotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 1480-1491 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	solanum anguivi phytochemical antioxidant activity antibacterial activity total phenol and total flavonoid contents Biotechnology TP248.13-248.65
spellingShingle	solanum anguivi phytochemical antioxidant activity antibacterial activity total phenol and total flavonoid contents Biotechnology TP248.13-248.65 Misganaw Tegegne Enkuahone Abiyu Solomon Libesu Belete Bedemo Mekuanint Lewoyehu Phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi
description	Solanum anguivi Lam. is an ethnomedicinal plant. Local traditional practitioners believe that it reduces the risk of diabetes and atherosclerosis diseases. The present study was intended to conduct qualitative phytochemical analysis, determine the total flavonoid and phenolic contents, estimate the antioxidant capacity and antibacterial activities of the extracts of the fruits of this plant. The antioxidant activity was determined by analyzing the radical scavenging activity (RSA) using 2,2-diphenyl-1-picryhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) assays. The antibacterial activities were determined by the agar well diffusion method. Qualitative phytochemical screening of the crude extracts obtained from the fruits of the plant indicated the presence of alkaloids, flavonoids, phenols, glycosides, steroids, terpenoids, saponins and tannins. The highest total phenolic and total flavonoid content were obtained in the ethanol extract of the fruits, followed by dichloromethane and n-hexane extract. The total phenolic content (in gallic acid equivalents, GAE) ranged from 113.3 to 202.72 mg GAE/g. The total flavonoid content (in catechin equivalent, CE) varied from 61.72 to 142.64 mg (CE)/g. All fruit extracts of S. anguivi exhibited antioxidant activity as revealed by DPPH and FRAP assays. The DPPH RSA (% inhibition) of the fruit extract varied from 35.11 to 80.13. The total phenolic and Flavonoid contents showed alinear correlation with RSA. Furthermore, all fruit extracts showed antibacterial activity against gram-positive and gram-negative bacteria varying from 12.5 to 16.75 mm. The result showed that the extracts of the plant exerted stronger bactericidal effect on gram-positive bacteria than on gram-negative bacteria. Supplemental data for this article is available online at https://doi.org/10.1080/13102818.2021.1993087 .
format	article
author	Misganaw Tegegne Enkuahone Abiyu Solomon Libesu Belete Bedemo Mekuanint Lewoyehu
author_facet	Misganaw Tegegne Enkuahone Abiyu Solomon Libesu Belete Bedemo Mekuanint Lewoyehu
author_sort	Misganaw Tegegne
title	Phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi
title_short	Phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi
title_full	Phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi
title_fullStr	Phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi
title_full_unstemmed	Phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi
title_sort	phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of solanum anguivi
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/d483a0674d7a4da9be992cc6452552e1
work_keys_str_mv	AT misganawtegegne phytochemicalinvestigationantioxidantandantibacterialactivitiesofthefruitextractsofsolanumanguivi AT enkuahoneabiyu phytochemicalinvestigationantioxidantandantibacterialactivitiesofthefruitextractsofsolanumanguivi AT solomonlibesu phytochemicalinvestigationantioxidantandantibacterialactivitiesofthefruitextractsofsolanumanguivi AT beletebedemo phytochemicalinvestigationantioxidantandantibacterialactivitiesofthefruitextractsofsolanumanguivi AT mekuanintlewoyehu phytochemicalinvestigationantioxidantandantibacterialactivitiesofthefruitextractsofsolanumanguivi
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Phytochemical investigation, antioxidant and antibacterial activities of the fruit extracts of Solanum anguivi

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