Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians

Christopher F Sharpley,1 Vicki Bitsika,2 Mary E McMillan,1 Emmanuel Jesulola,1 Linda L Agnew1 1Brain-Behaviour Research Group, University of New England, Armidale, NSW, Australia; 2Centre for Autism Spectrum Disorders, Bond University, Gold Coast, QLD, Australia Purpose: Depression remains difficu...

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Autores principales:	Sharpley CF, Bitsika V, McMillan ME, Jesulola E, Agnew LL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Genes mental health life experiences Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d48569f792a045b89efb5f1472f6c393
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spelling	oai:doaj.org-article:d48569f792a045b89efb5f1472f6c3932021-12-02T04:47:12ZAssociations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians1178-2021https://doaj.org/article/d48569f792a045b89efb5f1472f6c3932018-08-01T00:00:00Zhttps://www.dovepress.com/associations-between-stress-and-depression-symptom-profiles-vary-accor-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Christopher F Sharpley,1 Vicki Bitsika,2 Mary E McMillan,1 Emmanuel Jesulola,1 Linda L Agnew1 1Brain-Behaviour Research Group, University of New England, Armidale, NSW, Australia; 2Centre for Autism Spectrum Disorders, Bond University, Gold Coast, QLD, Australia Purpose: Depression remains difficult to treat in all cases, and further investigation of the role of genetic and environmental factors may be valuable. This study was designed to investigate the association between the short (s) versus non-short (non-s) 5HTTLPR variants, presence of childhood stressors and recent life stressors, and depression, and to do so at two levels that would expose the associations between total depression scores and also individual depression items.Materials and methods: Two hundred and forty-nine volunteers from one of the Australian Electoral Office electorates covering a large rural land area completed a series of questionnaires about childhood and recent life stress and depression, and provided a buccal cell sample for genotyping the 5-HTTLPR polymorphism into s versus non-s carriers.Results: Although there were no significant differences in the depression scores of the s-carriers versus the non-s carriers, each subtype of the 5-HTTLPR polymorphism showed different patterns of association between childhood stress and depression symptoms, and between recent life stress and depression symptoms.Conclusion: Individualization of therapy for depression may be achieved through consideration of the specific associations that patients exhibit between life stress, 5-HTTLPR polymorphism, and depression symptomatology. Keywords: genes, mental health, life experiencesSharpley CFBitsika VMcMillan MEJesulola EAgnew LLDove Medical PressarticleGenesmental healthlife experiencesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2007-2016 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genes mental health life experiences Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Genes mental health life experiences Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sharpley CF Bitsika V McMillan ME Jesulola E Agnew LL Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians
description	Christopher F Sharpley,1 Vicki Bitsika,2 Mary E McMillan,1 Emmanuel Jesulola,1 Linda L Agnew1 1Brain-Behaviour Research Group, University of New England, Armidale, NSW, Australia; 2Centre for Autism Spectrum Disorders, Bond University, Gold Coast, QLD, Australia Purpose: Depression remains difficult to treat in all cases, and further investigation of the role of genetic and environmental factors may be valuable. This study was designed to investigate the association between the short (s) versus non-short (non-s) 5HTTLPR variants, presence of childhood stressors and recent life stressors, and depression, and to do so at two levels that would expose the associations between total depression scores and also individual depression items.Materials and methods: Two hundred and forty-nine volunteers from one of the Australian Electoral Office electorates covering a large rural land area completed a series of questionnaires about childhood and recent life stress and depression, and provided a buccal cell sample for genotyping the 5-HTTLPR polymorphism into s versus non-s carriers.Results: Although there were no significant differences in the depression scores of the s-carriers versus the non-s carriers, each subtype of the 5-HTTLPR polymorphism showed different patterns of association between childhood stress and depression symptoms, and between recent life stress and depression symptoms.Conclusion: Individualization of therapy for depression may be achieved through consideration of the specific associations that patients exhibit between life stress, 5-HTTLPR polymorphism, and depression symptomatology. Keywords: genes, mental health, life experiences
format	article
author	Sharpley CF Bitsika V McMillan ME Jesulola E Agnew LL
author_facet	Sharpley CF Bitsika V McMillan ME Jesulola E Agnew LL
author_sort	Sharpley CF
title	Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians
title_short	Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians
title_full	Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians
title_fullStr	Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians
title_full_unstemmed	Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians
title_sort	associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural australians
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d48569f792a045b89efb5f1472f6c393
work_keys_str_mv	AT sharpleycf associationsbetweenstressanddepressionsymptomprofilesvaryaccordingtoserotonintransporterpolymorphisminruralaustralians AT bitsikav associationsbetweenstressanddepressionsymptomprofilesvaryaccordingtoserotonintransporterpolymorphisminruralaustralians AT mcmillanme associationsbetweenstressanddepressionsymptomprofilesvaryaccordingtoserotonintransporterpolymorphisminruralaustralians AT jesulolae associationsbetweenstressanddepressionsymptomprofilesvaryaccordingtoserotonintransporterpolymorphisminruralaustralians AT agnewll associationsbetweenstressanddepressionsymptomprofilesvaryaccordingtoserotonintransporterpolymorphisminruralaustralians
_version_	1718401037324255232

Associations between stress and depression symptom profiles vary according to serotonin transporter polymorphism in rural Australians

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