Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis

Abstract To study the correlation of OCT parameters including central subfield macular thickness (CSMT), peripapillary retinal thickness (PRT), and peripapillary retinal nerve fiber layer thickness (PNFLT) with fluorescein angiography (FA) in evaluation of inflammatory activity in Behcet’s retinal v...

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Autores principales:	Mohammad Zarei, Hossein Pesarakli, Mehdi Yaseri, Hamed Etesali, Nazanin Ebrahimiadib
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d48a9aa6980346749fff2c33c181fa53
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spelling	oai:doaj.org-article:d48a9aa6980346749fff2c33c181fa532021-12-02T16:56:48ZPeripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis10.1038/s41598-021-99485-52045-2322https://doaj.org/article/d48a9aa6980346749fff2c33c181fa532021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99485-5https://doaj.org/toc/2045-2322Abstract To study the correlation of OCT parameters including central subfield macular thickness (CSMT), peripapillary retinal thickness (PRT), and peripapillary retinal nerve fiber layer thickness (PNFLT) with fluorescein angiography (FA) in evaluation of inflammatory activity in Behcet’s retinal vasculitis. In this case-series, concurrent FA and OCT were performed. A scoring system was devised for FA. PNFLT in 3.4-mm-diameter circle as well as PRT in doughnut shaped regions between the 1-mm- and 2.2-mm-diameter and between the 2.2-mm- and 3.45-mm-diameter circles was measured. The correlation of FA and OCT parameters was analyzed. A total of 105 sets of FA from 28 eyes (15 patients) were reviewed. Four (26.6%) were female and mean age was 31.6 ± 8.49 years. Each micron increase in CSMT, PRT2.2, PRT3.45, and PNFLT, caused a rise of 0.018 (95% CI 0.008–0.027, P < 0.001, r = 0.413), 0.053 (95% CI 0.035–0.070, P < 0.001, r = 0.443), 0.086 (95% CI 0.065–0.108, P < 0.001, r = 0.707), and 0.185 (95% CI 0.152–to 0.218, P < 0.001, r = 0.850) unit in FA score, respectively. Parameters having significant correlation with angiographic inflammatory activity, were CSMT, PRT2.2, PRT3.45 and RNFLT. Those with the strongest correlation, PRT3.45 and PNFLT, may be considered as quantitative non-invasive alternatives to FA for monitoring Behcet’s retinal vasculitis.Mohammad ZareiHossein PesarakliMehdi YaseriHamed EtesaliNazanin EbrahimiadibNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Zarei Hossein Pesarakli Mehdi Yaseri Hamed Etesali Nazanin Ebrahimiadib Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis
description	Abstract To study the correlation of OCT parameters including central subfield macular thickness (CSMT), peripapillary retinal thickness (PRT), and peripapillary retinal nerve fiber layer thickness (PNFLT) with fluorescein angiography (FA) in evaluation of inflammatory activity in Behcet’s retinal vasculitis. In this case-series, concurrent FA and OCT were performed. A scoring system was devised for FA. PNFLT in 3.4-mm-diameter circle as well as PRT in doughnut shaped regions between the 1-mm- and 2.2-mm-diameter and between the 2.2-mm- and 3.45-mm-diameter circles was measured. The correlation of FA and OCT parameters was analyzed. A total of 105 sets of FA from 28 eyes (15 patients) were reviewed. Four (26.6%) were female and mean age was 31.6 ± 8.49 years. Each micron increase in CSMT, PRT2.2, PRT3.45, and PNFLT, caused a rise of 0.018 (95% CI 0.008–0.027, P < 0.001, r = 0.413), 0.053 (95% CI 0.035–0.070, P < 0.001, r = 0.443), 0.086 (95% CI 0.065–0.108, P < 0.001, r = 0.707), and 0.185 (95% CI 0.152–to 0.218, P < 0.001, r = 0.850) unit in FA score, respectively. Parameters having significant correlation with angiographic inflammatory activity, were CSMT, PRT2.2, PRT3.45 and RNFLT. Those with the strongest correlation, PRT3.45 and PNFLT, may be considered as quantitative non-invasive alternatives to FA for monitoring Behcet’s retinal vasculitis.
format	article
author	Mohammad Zarei Hossein Pesarakli Mehdi Yaseri Hamed Etesali Nazanin Ebrahimiadib
author_facet	Mohammad Zarei Hossein Pesarakli Mehdi Yaseri Hamed Etesali Nazanin Ebrahimiadib
author_sort	Mohammad Zarei
title	Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis
title_short	Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis
title_full	Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis
title_fullStr	Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis
title_full_unstemmed	Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis
title_sort	peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring behcet’s retinal vasculitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d48a9aa6980346749fff2c33c181fa53
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Peripapillary optical coherence tomography as an alternative to fluorescein angiography for monitoring Behcet’s retinal vasculitis

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