Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation

Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain nuclear integrity.

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Autores principales:	Yanan Zhang, Jiancheng Wang, Weijun Huang, Jianye Cai, Junhui Ba, Yi Wang, Qiong Ke, Yinong Huang, Xin Liu, Yuan Qiu, Qiying Lu, Xin Sui, Yue Shi, Tao Wang, Huiyong Shen, Yuanjun Guan, Ying Zhou, Yuan Chen, Maosheng Wang, Andy Peng Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d48c676e77354d918de1fbd1372346c0
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spelling	oai:doaj.org-article:d48c676e77354d918de1fbd1372346c02021-12-02T17:31:29ZNuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation10.1038/s41467-018-05808-y2041-1723https://doaj.org/article/d48c676e77354d918de1fbd1372346c02018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05808-yhttps://doaj.org/toc/2041-1723Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain nuclear integrity.Yanan ZhangJiancheng WangWeijun HuangJianye CaiJunhui BaYi WangQiong KeYinong HuangXin LiuYuan QiuQiying LuXin SuiYue ShiTao WangHuiyong ShenYuanjun GuanYing ZhouYuan ChenMaosheng WangAndy Peng XiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanan Zhang Jiancheng Wang Weijun Huang Jianye Cai Junhui Ba Yi Wang Qiong Ke Yinong Huang Xin Liu Yuan Qiu Qiying Lu Xin Sui Yue Shi Tao Wang Huiyong Shen Yuanjun Guan Ying Zhou Yuan Chen Maosheng Wang Andy Peng Xiang Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
description	Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain nuclear integrity.
format	article
author	Yanan Zhang Jiancheng Wang Weijun Huang Jianye Cai Junhui Ba Yi Wang Qiong Ke Yinong Huang Xin Liu Yuan Qiu Qiying Lu Xin Sui Yue Shi Tao Wang Huiyong Shen Yuanjun Guan Ying Zhou Yuan Chen Maosheng Wang Andy Peng Xiang
author_facet	Yanan Zhang Jiancheng Wang Weijun Huang Jianye Cai Junhui Ba Yi Wang Qiong Ke Yinong Huang Xin Liu Yuan Qiu Qiying Lu Xin Sui Yue Shi Tao Wang Huiyong Shen Yuanjun Guan Ying Zhou Yuan Chen Maosheng Wang Andy Peng Xiang
author_sort	Yanan Zhang
title	Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
title_short	Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
title_full	Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
title_fullStr	Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
title_full_unstemmed	Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
title_sort	nuclear nestin deficiency drives tumor senescence via lamin a/c-dependent nuclear deformation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d48c676e77354d918de1fbd1372346c0
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Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation

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