Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation

Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation

Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain nuclear integrity.

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Detalles Bibliográficos
Autores principales: Yanan Zhang, Jiancheng Wang, Weijun Huang, Jianye Cai, Junhui Ba, Yi Wang, Qiong Ke, Yinong Huang, Xin Liu, Yuan Qiu, Qiying Lu, Xin Sui, Yue Shi, Tao Wang, Huiyong Shen, Yuanjun Guan, Ying Zhou, Yuan Chen, Maosheng Wang, Andy Peng Xiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d48c676e77354d918de1fbd1372346c0
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