Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3

Plakophilins (PKPs) act as a key regulator of different signaling programs and control a variety of cellular processes ranging from transcription, protein synthesis, growth, proliferation, and tumor development. The function and possible mechanism of PKP3 in ovarian cancer (OC) remain unknown. It is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shujie Ruan, Jingping Shi, Ming Wang, Zhechen Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/d48ef7c63bfe4a16920238c4b8a216c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d48ef7c63bfe4a16920238c4b8a216c1
record_format	dspace
spelling	oai:doaj.org-article:d48ef7c63bfe4a16920238c4b8a216c12021-11-08T02:37:13ZAnalysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP32040-230910.1155/2021/9391104https://doaj.org/article/d48ef7c63bfe4a16920238c4b8a216c12021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9391104https://doaj.org/toc/2040-2309Plakophilins (PKPs) act as a key regulator of different signaling programs and control a variety of cellular processes ranging from transcription, protein synthesis, growth, proliferation, and tumor development. The function and possible mechanism of PKP3 in ovarian cancer (OC) remain unknown. It is extremely important to investigate the expression and prognostic values of PKP3, as well as their possible mechanisms, and immune infiltration in OC. Therefore, in this paper we explored the potential oncogenic role of PKP3 in 33 tumors based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The result outcomes showed that PKP3 is highly expressed in most cancers, and the expression level and prognosis of PKP3 showed little significance in cancer patients. Moreover, oncologists have found that members of the plakophilin family have different degrees of abnormality in ovarian cancer. PKP3 played a key part in carcinogenesis and aggressiveness of OC as well as malignant biological activity and can be used as a biomarker for early diagnosis and prognosis evaluation in OC.Shujie RuanJingping ShiMing WangZhechen ZhuHindawi LimitedarticleMedicine (General)R5-920Medical technologyR855-855.5ENJournal of Healthcare Engineering, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Medical technology R855-855.5
spellingShingle	Medicine (General) R5-920 Medical technology R855-855.5 Shujie Ruan Jingping Shi Ming Wang Zhechen Zhu Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3
description	Plakophilins (PKPs) act as a key regulator of different signaling programs and control a variety of cellular processes ranging from transcription, protein synthesis, growth, proliferation, and tumor development. The function and possible mechanism of PKP3 in ovarian cancer (OC) remain unknown. It is extremely important to investigate the expression and prognostic values of PKP3, as well as their possible mechanisms, and immune infiltration in OC. Therefore, in this paper we explored the potential oncogenic role of PKP3 in 33 tumors based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The result outcomes showed that PKP3 is highly expressed in most cancers, and the expression level and prognosis of PKP3 showed little significance in cancer patients. Moreover, oncologists have found that members of the plakophilin family have different degrees of abnormality in ovarian cancer. PKP3 played a key part in carcinogenesis and aggressiveness of OC as well as malignant biological activity and can be used as a biomarker for early diagnosis and prognosis evaluation in OC.
format	article
author	Shujie Ruan Jingping Shi Ming Wang Zhechen Zhu
author_facet	Shujie Ruan Jingping Shi Ming Wang Zhechen Zhu
author_sort	Shujie Ruan
title	Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3
title_short	Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3
title_full	Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3
title_fullStr	Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3
title_full_unstemmed	Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3
title_sort	analysis of multiple human tumor cases reveals the carcinogenic effects of pkp3
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d48ef7c63bfe4a16920238c4b8a216c1
work_keys_str_mv	AT shujieruan analysisofmultiplehumantumorcasesrevealsthecarcinogeniceffectsofpkp3 AT jingpingshi analysisofmultiplehumantumorcasesrevealsthecarcinogeniceffectsofpkp3 AT mingwang analysisofmultiplehumantumorcasesrevealsthecarcinogeniceffectsofpkp3 AT zhechenzhu analysisofmultiplehumantumorcasesrevealsthecarcinogeniceffectsofpkp3
_version_	1718443044619943936

Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3

Ejemplares similares