Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan

Introduction Colorectal cancer (CRC) is rapidly increasing in developed countries. In Taiwan, the incidence rate of CRC has increased during the past decade, but the 5-year survival has remained at approximately 63%. In this study, we sought to determine the 5-year survival rate of patients diagnose...

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Autores principales:	Chao-Hsien Lee, Peng-Lin Tseng, Hong-Yi Tung, Shu-Chen Cheng, Ching-Yun Ching, Shih-Chang Chang, Shu-Fen Wu
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	colorectal cancer risk factors survival colon cancer rectum cancer Medicine R
Acceso en línea:	https://doaj.org/article/d4933a84fee14258920a862a5e4fb842
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spelling	oai:doaj.org-article:d4933a84fee14258920a862a5e4fb8422021-12-02T16:59:25ZComparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan1734-19221896-915110.5114/aoms.2019.89407https://doaj.org/article/d4933a84fee14258920a862a5e4fb8422019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Comparison-of-risk-factors-between-colon-cancer-and-rectum-cancer-in-a-single-medical,76952,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Colorectal cancer (CRC) is rapidly increasing in developed countries. In Taiwan, the incidence rate of CRC has increased during the past decade, but the 5-year survival has remained at approximately 63%. In this study, we sought to determine the 5-year survival rate of patients diagnosed with colon and rectum cancer and to determine factors affecting survival. Material and methods All patients from the Taiwan Cancer Database of the medical center hospital in North Taiwan between 2007 and 2013 were identified. Survival analysis was performed using Kaplan-Meier curves, and differences between the curves were analyzed using the log-rank test. Cox proportional hazards regression models were used to analyze survival by each variable. Results A total of 869 patients were included: 554 (63.8%) patients had colon cancer and 315 (36.2%) had rectum cancer. The mean survival time was 71.27 ±1.27 months (colon group: 71.90 ±1.58 months; rectum group: 67.88 ±1.95 months). There was no significant difference (p = 0.493) between patients who had colon or rectum cancer. The forward stepwise Cox regression analysis results indicated that perineural invasion, distant metastasis, age, pathological differentiation grade, and obstruction were statistically significant for patients who had CRC, colon cancer or rectum cancer. Conclusions The long-term survival from CRC, colon cancer and rectum cancer remains promising, as 68.66%, 69.11% and 67.90% of patients are alive 5 years after being diagnosed, respectively. Perineural invasion was found to be an important factor related to the survival of patients who have CRC. Thus, early detection of CRC may help improve survival.Chao-Hsien LeePeng-Lin TsengHong-Yi TungShu-Chen ChengChing-Yun ChingShih-Chang ChangShu-Fen WuTermedia Publishing Housearticlecolorectal cancerrisk factorssurvivalcolon cancerrectum cancerMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 102-111 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer risk factors survival colon cancer rectum cancer Medicine R
spellingShingle	colorectal cancer risk factors survival colon cancer rectum cancer Medicine R Chao-Hsien Lee Peng-Lin Tseng Hong-Yi Tung Shu-Chen Cheng Ching-Yun Ching Shih-Chang Chang Shu-Fen Wu Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan
description	Introduction Colorectal cancer (CRC) is rapidly increasing in developed countries. In Taiwan, the incidence rate of CRC has increased during the past decade, but the 5-year survival has remained at approximately 63%. In this study, we sought to determine the 5-year survival rate of patients diagnosed with colon and rectum cancer and to determine factors affecting survival. Material and methods All patients from the Taiwan Cancer Database of the medical center hospital in North Taiwan between 2007 and 2013 were identified. Survival analysis was performed using Kaplan-Meier curves, and differences between the curves were analyzed using the log-rank test. Cox proportional hazards regression models were used to analyze survival by each variable. Results A total of 869 patients were included: 554 (63.8%) patients had colon cancer and 315 (36.2%) had rectum cancer. The mean survival time was 71.27 ±1.27 months (colon group: 71.90 ±1.58 months; rectum group: 67.88 ±1.95 months). There was no significant difference (p = 0.493) between patients who had colon or rectum cancer. The forward stepwise Cox regression analysis results indicated that perineural invasion, distant metastasis, age, pathological differentiation grade, and obstruction were statistically significant for patients who had CRC, colon cancer or rectum cancer. Conclusions The long-term survival from CRC, colon cancer and rectum cancer remains promising, as 68.66%, 69.11% and 67.90% of patients are alive 5 years after being diagnosed, respectively. Perineural invasion was found to be an important factor related to the survival of patients who have CRC. Thus, early detection of CRC may help improve survival.
format	article
author	Chao-Hsien Lee Peng-Lin Tseng Hong-Yi Tung Shu-Chen Cheng Ching-Yun Ching Shih-Chang Chang Shu-Fen Wu
author_facet	Chao-Hsien Lee Peng-Lin Tseng Hong-Yi Tung Shu-Chen Cheng Ching-Yun Ching Shih-Chang Chang Shu-Fen Wu
author_sort	Chao-Hsien Lee
title	Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan
title_short	Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan
title_full	Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan
title_fullStr	Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan
title_full_unstemmed	Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan
title_sort	comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, taiwan
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/d4933a84fee14258920a862a5e4fb842
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Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan

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