Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach

Introduction: The purpose of our study is to detect and compare common, significantly enriched pathways in peripheral blood mononuclears (PBMC) and CNS tissue donated by idiopathic Parkinson's Disease (iPD) patients and compare their transcriptomic profiles with those donated by tuberculosis (T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	George D. Vavougios, Sotirios Zarogiannis, Debmalya Barh, Marianthi Breza, Karen A. Krogfelt, George Stamoulis, Konstantinos I. Gourgoulianis
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Parkinson's disease Tuberculosis Mycobacteria Pathway Enrichment Systems Biology Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d49716d6f86c42049248b0c394e57a24
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d49716d6f86c42049248b0c394e57a24
record_format	dspace
spelling	oai:doaj.org-article:d49716d6f86c42049248b0c394e57a242021-11-18T04:52:19ZInnate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach2666-459310.1016/j.dscb.2021.100025https://doaj.org/article/d49716d6f86c42049248b0c394e57a242021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S266645932100024Xhttps://doaj.org/toc/2666-4593Introduction: The purpose of our study is to detect and compare common, significantly enriched pathways in peripheral blood mononuclears (PBMC) and CNS tissue donated by idiopathic Parkinson's Disease (iPD) patients and compare their transcriptomic profiles with those donated by tuberculosis (TB) patients. Methods: We performed comparative transcriptomic analyses between gene expression studies published in the GEO Datasets repository, retrieved as queries of iPD and TB each vs healthy controls. Results: Datasets retrieved involved iPD: 2 PBMC studies, 1 Substantia Nigra (SN) and 1 Dorsal Motor Nucleus of the Vagus (DMNV) study, as well as TB: 1 PBMC and one study with monocyte (Mc) gene expression profiles. Among significantly enriched pathways were the influenza A (IAV) associated “Viral mRNA Translation” and “L13a-mediated translational silencing of Ceruloplasmin expression”, common between DMNV, active Tb Monocytes (TBA Mc), post-treatment TB and both iPD PBMC datasets. Discussion: Our results support the hypothesis that remnant, postinfectious epigenetic changes on PBMCs inflicted by Mycobacterium Tuberculosis (Mtb) may alter their phenotype, facilitating non-abortive intracellular residency for a subsequent pathogen. This pathogen may be transmissible to the CNS via sites such as the vagal projections, and prime iPD pathogenesis by disrupting metal ion homeostasis in a lifecycle – dependent manner.George D. VavougiosSotirios ZarogiannisDebmalya BarhMarianthi BrezaKaren A. KrogfeltGeorge StamoulisKonstantinos I. GourgoulianisElsevierarticleParkinson's diseaseTuberculosisMycobacteriaPathway EnrichmentSystems BiologyNeurology. Diseases of the nervous systemRC346-429ENBrain Disorders, Vol 4, Iss , Pp 100025- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson's disease Tuberculosis Mycobacteria Pathway Enrichment Systems Biology Neurology. Diseases of the nervous system RC346-429
spellingShingle	Parkinson's disease Tuberculosis Mycobacteria Pathway Enrichment Systems Biology Neurology. Diseases of the nervous system RC346-429 George D. Vavougios Sotirios Zarogiannis Debmalya Barh Marianthi Breza Karen A. Krogfelt George Stamoulis Konstantinos I. Gourgoulianis Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach
description	Introduction: The purpose of our study is to detect and compare common, significantly enriched pathways in peripheral blood mononuclears (PBMC) and CNS tissue donated by idiopathic Parkinson's Disease (iPD) patients and compare their transcriptomic profiles with those donated by tuberculosis (TB) patients. Methods: We performed comparative transcriptomic analyses between gene expression studies published in the GEO Datasets repository, retrieved as queries of iPD and TB each vs healthy controls. Results: Datasets retrieved involved iPD: 2 PBMC studies, 1 Substantia Nigra (SN) and 1 Dorsal Motor Nucleus of the Vagus (DMNV) study, as well as TB: 1 PBMC and one study with monocyte (Mc) gene expression profiles. Among significantly enriched pathways were the influenza A (IAV) associated “Viral mRNA Translation” and “L13a-mediated translational silencing of Ceruloplasmin expression”, common between DMNV, active Tb Monocytes (TBA Mc), post-treatment TB and both iPD PBMC datasets. Discussion: Our results support the hypothesis that remnant, postinfectious epigenetic changes on PBMCs inflicted by Mycobacterium Tuberculosis (Mtb) may alter their phenotype, facilitating non-abortive intracellular residency for a subsequent pathogen. This pathogen may be transmissible to the CNS via sites such as the vagal projections, and prime iPD pathogenesis by disrupting metal ion homeostasis in a lifecycle – dependent manner.
format	article
author	George D. Vavougios Sotirios Zarogiannis Debmalya Barh Marianthi Breza Karen A. Krogfelt George Stamoulis Konstantinos I. Gourgoulianis
author_facet	George D. Vavougios Sotirios Zarogiannis Debmalya Barh Marianthi Breza Karen A. Krogfelt George Stamoulis Konstantinos I. Gourgoulianis
author_sort	George D. Vavougios
title	Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach
title_short	Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach
title_full	Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach
title_fullStr	Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach
title_full_unstemmed	Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach
title_sort	innate immunity and metal ion trafficking pathway perturbations in idiopathic parkinson's disease and tuberculosis: a comparative transcriptomics approach
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d49716d6f86c42049248b0c394e57a24
work_keys_str_mv	AT georgedvavougios innateimmunityandmetaliontraffickingpathwayperturbationsinidiopathicparkinsonsdiseaseandtuberculosisacomparativetranscriptomicsapproach AT sotirioszarogiannis innateimmunityandmetaliontraffickingpathwayperturbationsinidiopathicparkinsonsdiseaseandtuberculosisacomparativetranscriptomicsapproach AT debmalyabarh innateimmunityandmetaliontraffickingpathwayperturbationsinidiopathicparkinsonsdiseaseandtuberculosisacomparativetranscriptomicsapproach AT marianthibreza innateimmunityandmetaliontraffickingpathwayperturbationsinidiopathicparkinsonsdiseaseandtuberculosisacomparativetranscriptomicsapproach AT karenakrogfelt innateimmunityandmetaliontraffickingpathwayperturbationsinidiopathicparkinsonsdiseaseandtuberculosisacomparativetranscriptomicsapproach AT georgestamoulis innateimmunityandmetaliontraffickingpathwayperturbationsinidiopathicparkinsonsdiseaseandtuberculosisacomparativetranscriptomicsapproach AT konstantinosigourgoulianis innateimmunityandmetaliontraffickingpathwayperturbationsinidiopathicparkinsonsdiseaseandtuberculosisacomparativetranscriptomicsapproach
_version_	1718425005352550400

Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach

Ejemplares similares