Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

A RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-51-ssDNA complexes with optimal nucleotide content.

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Autores principales:	Mário Špírek, Martin R. G. Taylor, Ondrej Belan, Simon J. Boulton, Lumir Krejci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d49c4a80c40642788272abc5c212eb04
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spelling	oai:doaj.org-article:d49c4a80c40642788272abc5c212eb042021-12-02T17:26:56ZNucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function10.1038/s41467-021-25830-x2041-1723https://doaj.org/article/d49c4a80c40642788272abc5c212eb042021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25830-xhttps://doaj.org/toc/2041-1723A RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-51-ssDNA complexes with optimal nucleotide content.Mário ŠpírekMartin R. G. TaylorOndrej BelanSimon J. BoultonLumir KrejciNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mário Špírek Martin R. G. Taylor Ondrej Belan Simon J. Boulton Lumir Krejci Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
description	A RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-51-ssDNA complexes with optimal nucleotide content.
format	article
author	Mário Špírek Martin R. G. Taylor Ondrej Belan Simon J. Boulton Lumir Krejci
author_facet	Mário Špírek Martin R. G. Taylor Ondrej Belan Simon J. Boulton Lumir Krejci
author_sort	Mário Špírek
title	Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_short	Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_full	Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_fullStr	Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_full_unstemmed	Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
title_sort	nucleotide proofreading functions by nematode rad51 paralogs facilitate optimal rad51 filament function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d49c4a80c40642788272abc5c212eb04
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Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

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