Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

A RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-51-ssDNA complexes with optimal nucleotide content.

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Autores principales: Mário Špírek, Martin R. G. Taylor, Ondrej Belan, Simon J. Boulton, Lumir Krejci
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/d49c4a80c40642788272abc5c212eb04
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