Site-directed mutations in the C-terminal extension of human alphaB-crystallin affect chaperone function and block amyloid fibril formation.

Site-directed mutations in the C-terminal extension of human alphaB-crystallin affect chaperone function and block amyloid fibril formation.

<h4>Background</h4>Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate protein deposition and ordered amyloid fibril assembly. Molecular chaperones, including alphaB-crystallin, play a role in the prevention of protein deposition.<h4>M...

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Autores principales: Teresa M Treweek, Heath Ecroyd, Danielle M Williams, Sarah Meehan, John A Carver, Mark J Walker
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2007
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/d49f0f914aee4690b4b52bada14e2151
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