Relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain

Abstract Abdominal pain has been associated with disaccharidase deficiencies. While relationships with individual symptoms have been assessed, relationships between disaccharidase deficiencies and symptom complexes or inflammation have not been evaluated in this group. The primary aims of the curren...

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Autores principales:	Jennifer M. Colombo, Chance S. Friesen, Uttam Garg, Craig A. Friesen, William San Pablo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4a1a39298b3434ea02280a073f403bc
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spelling	oai:doaj.org-article:d4a1a39298b3434ea02280a073f403bc2021-12-02T13:20:13ZRelationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain10.1038/s41598-021-84535-92045-2322https://doaj.org/article/d4a1a39298b3434ea02280a073f403bc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84535-9https://doaj.org/toc/2045-2322Abstract Abdominal pain has been associated with disaccharidase deficiencies. While relationships with individual symptoms have been assessed, relationships between disaccharidase deficiencies and symptom complexes or inflammation have not been evaluated in this group. The primary aims of the current study were to assess relationships between disaccharidase deficiency and symptoms or symptom complexes and duodenal inflammation, respectively. Patients with abdominal pain who underwent endoscopy with evaluation of disaccharidase activity levels were identified. After excluding all patients with inflammatory bowel disease, celiac disease, H. pylori, or gross endoscopic lesions, patients were evaluated for disaccharidase deficiency frequency. Disaccharidase were compared between patients with and without histologic duodenitis. Lastly, relationships between individual gastrointestinal symptoms or symptom complexes were evaluated. Lactase deficiency was found in 34.3% of patients and disaccharidase pan-deficiency in 7.6%. No individual symptoms or symptom complexes predicted disaccharidase deficiency. While duodenitis was not associated with disaccharidase deficiency, it was only present in 5.9% of patients. Disaccharidase deficiency, particularly lactase deficiency, is common in youth with abdominal pain and multiple deficiencies are not uncommon. Disaccharidase deficiency cannot be predicted by symptoms in this population. Further studies are needed to assess the clinical significance of disaccharidase deficiency.Jennifer M. ColomboChance S. FriesenUttam GargCraig A. FriesenWilliam San PabloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer M. Colombo Chance S. Friesen Uttam Garg Craig A. Friesen William San Pablo Relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain
description	Abstract Abdominal pain has been associated with disaccharidase deficiencies. While relationships with individual symptoms have been assessed, relationships between disaccharidase deficiencies and symptom complexes or inflammation have not been evaluated in this group. The primary aims of the current study were to assess relationships between disaccharidase deficiency and symptoms or symptom complexes and duodenal inflammation, respectively. Patients with abdominal pain who underwent endoscopy with evaluation of disaccharidase activity levels were identified. After excluding all patients with inflammatory bowel disease, celiac disease, H. pylori, or gross endoscopic lesions, patients were evaluated for disaccharidase deficiency frequency. Disaccharidase were compared between patients with and without histologic duodenitis. Lastly, relationships between individual gastrointestinal symptoms or symptom complexes were evaluated. Lactase deficiency was found in 34.3% of patients and disaccharidase pan-deficiency in 7.6%. No individual symptoms or symptom complexes predicted disaccharidase deficiency. While duodenitis was not associated with disaccharidase deficiency, it was only present in 5.9% of patients. Disaccharidase deficiency, particularly lactase deficiency, is common in youth with abdominal pain and multiple deficiencies are not uncommon. Disaccharidase deficiency cannot be predicted by symptoms in this population. Further studies are needed to assess the clinical significance of disaccharidase deficiency.
format	article
author	Jennifer M. Colombo Chance S. Friesen Uttam Garg Craig A. Friesen William San Pablo
author_facet	Jennifer M. Colombo Chance S. Friesen Uttam Garg Craig A. Friesen William San Pablo
author_sort	Jennifer M. Colombo
title	Relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain
title_short	Relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain
title_full	Relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain
title_fullStr	Relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain
title_full_unstemmed	Relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain
title_sort	relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d4a1a39298b3434ea02280a073f403bc
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Relationships between disaccharidase deficiencies, duodenal inflammation and symptom profile in children with abdominal pain

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