Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.

Whether dietary antioxidants are effective for alleviating oxidative costs associated with energy-demanding life events first requires they are successfully absorbed in the digestive tract and transported to sites associated with reactive species production (e.g. the mitochondria). Flying birds are...

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Autores principales:	Clara Cooper-Mullin, Wales A Carter, Ronald S Amato, David Podlesak, Scott R McWilliams
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4a4c8d029e64525b519c1c097a63266
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spelling	oai:doaj.org-article:d4a4c8d029e64525b519c1c097a632662021-12-02T20:09:55ZDietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.1932-620310.1371/journal.pone.0253264https://doaj.org/article/d4a4c8d029e64525b519c1c097a632662021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253264https://doaj.org/toc/1932-6203Whether dietary antioxidants are effective for alleviating oxidative costs associated with energy-demanding life events first requires they are successfully absorbed in the digestive tract and transported to sites associated with reactive species production (e.g. the mitochondria). Flying birds are under high energy and oxidative demands, and although birds commonly ingest dietary antioxidants in the wild, the bioavailability of these consumed antioxidants is poorly understood. We show for the first time that an ingested lipophilic antioxidant, α-tocopherol, reached the mitochondria in the flight muscles of a songbird but only if they regularly exercise (60 min of perch-to-perch flights two times in a day or 8.5 km day-1). Deuterated α-tocopherol was found in the blood of exercise-trained zebra finches within 6.5 hrs and in isolated mitochondria from pectoral muscle within 22.5 hrs, but never reached the mitochondria in caged sedentary control birds. This rapid pace (within a day) and extent of metabolic routing of a dietary antioxidant to muscle mitochondria means that daily consumption of such dietary sources can help to pay the inevitable oxidative costs of flight muscle metabolism, but only when combined with regular exercise.Clara Cooper-MullinWales A CarterRonald S AmatoDavid PodlesakScott R McWilliamsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253264 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clara Cooper-Mullin Wales A Carter Ronald S Amato David Podlesak Scott R McWilliams Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.
description	Whether dietary antioxidants are effective for alleviating oxidative costs associated with energy-demanding life events first requires they are successfully absorbed in the digestive tract and transported to sites associated with reactive species production (e.g. the mitochondria). Flying birds are under high energy and oxidative demands, and although birds commonly ingest dietary antioxidants in the wild, the bioavailability of these consumed antioxidants is poorly understood. We show for the first time that an ingested lipophilic antioxidant, α-tocopherol, reached the mitochondria in the flight muscles of a songbird but only if they regularly exercise (60 min of perch-to-perch flights two times in a day or 8.5 km day-1). Deuterated α-tocopherol was found in the blood of exercise-trained zebra finches within 6.5 hrs and in isolated mitochondria from pectoral muscle within 22.5 hrs, but never reached the mitochondria in caged sedentary control birds. This rapid pace (within a day) and extent of metabolic routing of a dietary antioxidant to muscle mitochondria means that daily consumption of such dietary sources can help to pay the inevitable oxidative costs of flight muscle metabolism, but only when combined with regular exercise.
format	article
author	Clara Cooper-Mullin Wales A Carter Ronald S Amato David Podlesak Scott R McWilliams
author_facet	Clara Cooper-Mullin Wales A Carter Ronald S Amato David Podlesak Scott R McWilliams
author_sort	Clara Cooper-Mullin
title	Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.
title_short	Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.
title_full	Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.
title_fullStr	Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.
title_full_unstemmed	Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.
title_sort	dietary vitamin e reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d4a4c8d029e64525b519c1c097a63266
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Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise.

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