Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.

Gene duplication was prevalent during hominoid evolution, yet little is known about the functional fate of new ape gene copies. We characterized the CDC14B cell cycle gene and the functional evolution of its hominoid-specific daughter gene, CDC14Bretro. We found that CDC14B encodes four different sp...

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Autores principales:	Lia Rosso, Ana Claudia Marques, Manuela Weier, Nelle Lambert, Marie-Alexandra Lambot, Pierre Vanderhaeghen, Henrik Kaessmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d4a4dde8b83c4a63960fbe975e3481c3
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spelling	oai:doaj.org-article:d4a4dde8b83c4a63960fbe975e3481c32021-11-25T05:33:19ZBirth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.1544-91731545-788510.1371/journal.pbio.0060140https://doaj.org/article/d4a4dde8b83c4a63960fbe975e3481c32008-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18547142/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Gene duplication was prevalent during hominoid evolution, yet little is known about the functional fate of new ape gene copies. We characterized the CDC14B cell cycle gene and the functional evolution of its hominoid-specific daughter gene, CDC14Bretro. We found that CDC14B encodes four different splice isoforms that show different subcellular localizations (nucleus or microtubule-associated) and functional properties. A microtubular CDC14B variant spawned CDC14Bretro through retroposition in the hominoid ancestor 18-25 million years ago (Mya). CDC14Bretro evolved brain-/testis-specific expression after the duplication event and experienced a short period of intense positive selection in the African ape ancestor 7-12 Mya. Using resurrected ancestral protein variants, we demonstrate that by virtue of amino acid substitutions in distinct protein regions during this time, the subcellular localization of CDC14Bretro progressively shifted from the association with microtubules (stabilizing them) to an association with the endoplasmic reticulum. CDC14Bretro evolution represents a paradigm example of rapid, selectively driven subcellular relocalization, thus revealing a novel mode for the emergence of new gene function.Lia RossoAna Claudia MarquesManuela WeierNelle LambertMarie-Alexandra LambotPierre VanderhaeghenHenrik KaessmannPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 6, p e140 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lia Rosso Ana Claudia Marques Manuela Weier Nelle Lambert Marie-Alexandra Lambot Pierre Vanderhaeghen Henrik Kaessmann Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.
description	Gene duplication was prevalent during hominoid evolution, yet little is known about the functional fate of new ape gene copies. We characterized the CDC14B cell cycle gene and the functional evolution of its hominoid-specific daughter gene, CDC14Bretro. We found that CDC14B encodes four different splice isoforms that show different subcellular localizations (nucleus or microtubule-associated) and functional properties. A microtubular CDC14B variant spawned CDC14Bretro through retroposition in the hominoid ancestor 18-25 million years ago (Mya). CDC14Bretro evolved brain-/testis-specific expression after the duplication event and experienced a short period of intense positive selection in the African ape ancestor 7-12 Mya. Using resurrected ancestral protein variants, we demonstrate that by virtue of amino acid substitutions in distinct protein regions during this time, the subcellular localization of CDC14Bretro progressively shifted from the association with microtubules (stabilizing them) to an association with the endoplasmic reticulum. CDC14Bretro evolution represents a paradigm example of rapid, selectively driven subcellular relocalization, thus revealing a novel mode for the emergence of new gene function.
format	article
author	Lia Rosso Ana Claudia Marques Manuela Weier Nelle Lambert Marie-Alexandra Lambot Pierre Vanderhaeghen Henrik Kaessmann
author_facet	Lia Rosso Ana Claudia Marques Manuela Weier Nelle Lambert Marie-Alexandra Lambot Pierre Vanderhaeghen Henrik Kaessmann
author_sort	Lia Rosso
title	Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.
title_short	Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.
title_full	Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.
title_fullStr	Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.
title_full_unstemmed	Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.
title_sort	birth and rapid subcellular adaptation of a hominoid-specific cdc14 protein.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/d4a4dde8b83c4a63960fbe975e3481c3
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Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.

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