Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy

The tumor microenvironment (TME) is composed of a heterogenous population of cells that exist alongside the extracellular matrix and soluble components. These components can shape an environment that is conducive to tumor growth and metastatic spread. It is well-established that stromal cancer-assoc...

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Autores principales:	Amr Allam, Marina Yakou, Lokman Pang, Matthias Ernst, Jennifer Huynh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	STAT (signal transducer and activator of transcription) tumor development cancer associated fibroblasts (CAF) cytokines tumor microenvironment Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d4a5077b598e480abc59c2ccf7573b8a
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spelling	oai:doaj.org-article:d4a5077b598e480abc59c2ccf7573b8a2021-11-11T08:33:05ZExploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy1664-322410.3389/fimmu.2021.767939https://doaj.org/article/d4a5077b598e480abc59c2ccf7573b8a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.767939/fullhttps://doaj.org/toc/1664-3224The tumor microenvironment (TME) is composed of a heterogenous population of cells that exist alongside the extracellular matrix and soluble components. These components can shape an environment that is conducive to tumor growth and metastatic spread. It is well-established that stromal cancer-associated fibroblasts (CAFs) in the TME play a pivotal role in creating and maintaining a growth-permissive environment for tumor cells. A growing body of work has uncovered that tumor cells recruit and educate CAFs to remodel the TME, however, the mechanisms by which this occurs remain incompletely understood. Recent studies suggest that the signal transducer and activator of transcription 3 (STAT3) is a key transcription factor that regulates the function of CAFs, and their crosstalk with tumor and immune cells within the TME. CAF-intrinsic STAT3 activity within the TME correlates with tumor progression, immune suppression and eventually the establishment of metastases. In this review, we will focus on the roles of STAT3 in regulating CAF function and their crosstalk with other cells constituting the TME and discuss the utility of targeting STAT3 within the TME for therapeutic benefit.Amr AllamMarina YakouLokman PangMatthias ErnstJennifer HuynhFrontiers Media S.A.articleSTAT (signal transducer and activator of transcription)tumor developmentcancer associated fibroblasts (CAF)cytokinestumor microenvironmentImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	STAT (signal transducer and activator of transcription) tumor development cancer associated fibroblasts (CAF) cytokines tumor microenvironment Immunologic diseases. Allergy RC581-607
spellingShingle	STAT (signal transducer and activator of transcription) tumor development cancer associated fibroblasts (CAF) cytokines tumor microenvironment Immunologic diseases. Allergy RC581-607 Amr Allam Marina Yakou Lokman Pang Matthias Ernst Jennifer Huynh Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy
description	The tumor microenvironment (TME) is composed of a heterogenous population of cells that exist alongside the extracellular matrix and soluble components. These components can shape an environment that is conducive to tumor growth and metastatic spread. It is well-established that stromal cancer-associated fibroblasts (CAFs) in the TME play a pivotal role in creating and maintaining a growth-permissive environment for tumor cells. A growing body of work has uncovered that tumor cells recruit and educate CAFs to remodel the TME, however, the mechanisms by which this occurs remain incompletely understood. Recent studies suggest that the signal transducer and activator of transcription 3 (STAT3) is a key transcription factor that regulates the function of CAFs, and their crosstalk with tumor and immune cells within the TME. CAF-intrinsic STAT3 activity within the TME correlates with tumor progression, immune suppression and eventually the establishment of metastases. In this review, we will focus on the roles of STAT3 in regulating CAF function and their crosstalk with other cells constituting the TME and discuss the utility of targeting STAT3 within the TME for therapeutic benefit.
format	article
author	Amr Allam Marina Yakou Lokman Pang Matthias Ernst Jennifer Huynh
author_facet	Amr Allam Marina Yakou Lokman Pang Matthias Ernst Jennifer Huynh
author_sort	Amr Allam
title	Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy
title_short	Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy
title_full	Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy
title_fullStr	Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy
title_full_unstemmed	Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy
title_sort	exploiting the stat3 nexus in cancer-associated fibroblasts to improve cancer therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d4a5077b598e480abc59c2ccf7573b8a
work_keys_str_mv	AT amrallam exploitingthestat3nexusincancerassociatedfibroblaststoimprovecancertherapy AT marinayakou exploitingthestat3nexusincancerassociatedfibroblaststoimprovecancertherapy AT lokmanpang exploitingthestat3nexusincancerassociatedfibroblaststoimprovecancertherapy AT matthiasernst exploitingthestat3nexusincancerassociatedfibroblaststoimprovecancertherapy AT jenniferhuynh exploitingthestat3nexusincancerassociatedfibroblaststoimprovecancertherapy
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Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy

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