Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain

Even today, the mortality rate for uveal melanoma (UM) remains very high. In our research, we sought to determine which pathological and clinical features were correlated with the prognosis of UM. BAP1 (BRCA1-Associated Protein 1) gene mutation has been analyzed as one of the strongest predictors fo...

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Autores principales:	Laura Tabuenca Del Barrio, Luiz Miguel Nova-Camacho, Alicia Zubicoa Enériz, Iñigo Martínez de Espronceda Ezquerro, Alicia Córdoba Iturriagagoitia, Enrique Borque Rodríguez-Maimón, Alfredo García-Layana
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	uveal melanoma metastasis survival BAP1 immunohistochemical stain prognostic factors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d4a6473c3b58421ca6e9828f168ecf99
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spelling	oai:doaj.org-article:d4a6473c3b58421ca6e9828f168ecf992021-11-11T15:28:48ZPrognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain10.3390/cancers132153472072-6694https://doaj.org/article/d4a6473c3b58421ca6e9828f168ecf992021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5347https://doaj.org/toc/2072-6694Even today, the mortality rate for uveal melanoma (UM) remains very high. In our research, we sought to determine which pathological and clinical features were correlated with the prognosis of UM. BAP1 (BRCA1-Associated Protein 1) gene mutation has been analyzed as one of the strongest predictors for metastasis in UM. The BAP1 gene codifies the BAP1 protein which has a tumor suppressor function. The presence of this protein can be determined by BAP1 immunohistochemical staining. Eighty-four uveal melanoma patients and forty enucleated eyeballs were examined. Metastasis was present in 24 patients. Nuclear BAP1 staining was low in 23 patients. The presence of a higher large basal diameter tumor (<i>p</i> < 0.001), tumor infiltrating lymphocytes (<i>p</i> = 0.020), and a lack of nuclear BAP1 immunostaining (<i>p</i> = 0.001) ocurred significantly more often in the metastatic group. Metastasis-free survival was lower in patients with low nuclear BAP1 staining (<i>p</i> = 0.003). In conclusion, to the best of our knowledge, this is the first time that BAP1 staining has been studied in uveal melanoma in a Spanish community. We believe that this technique should become routine in the pathological examination of uveal melanoma in order to allow adequate classification of patients and to establish an individual follow-up plan.Laura Tabuenca Del BarrioLuiz Miguel Nova-CamachoAlicia Zubicoa EnérizIñigo Martínez de Espronceda EzquerroAlicia Córdoba IturriagagoitiaEnrique Borque Rodríguez-MaimónAlfredo García-LayanaMDPI AGarticleuveal melanomametastasissurvivalBAP1 immunohistochemical stainprognostic factorsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5347, p 5347 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uveal melanoma metastasis survival BAP1 immunohistochemical stain prognostic factors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	uveal melanoma metastasis survival BAP1 immunohistochemical stain prognostic factors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Laura Tabuenca Del Barrio Luiz Miguel Nova-Camacho Alicia Zubicoa Enériz Iñigo Martínez de Espronceda Ezquerro Alicia Córdoba Iturriagagoitia Enrique Borque Rodríguez-Maimón Alfredo García-Layana Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain
description	Even today, the mortality rate for uveal melanoma (UM) remains very high. In our research, we sought to determine which pathological and clinical features were correlated with the prognosis of UM. BAP1 (BRCA1-Associated Protein 1) gene mutation has been analyzed as one of the strongest predictors for metastasis in UM. The BAP1 gene codifies the BAP1 protein which has a tumor suppressor function. The presence of this protein can be determined by BAP1 immunohistochemical staining. Eighty-four uveal melanoma patients and forty enucleated eyeballs were examined. Metastasis was present in 24 patients. Nuclear BAP1 staining was low in 23 patients. The presence of a higher large basal diameter tumor (<i>p</i> < 0.001), tumor infiltrating lymphocytes (<i>p</i> = 0.020), and a lack of nuclear BAP1 immunostaining (<i>p</i> = 0.001) ocurred significantly more often in the metastatic group. Metastasis-free survival was lower in patients with low nuclear BAP1 staining (<i>p</i> = 0.003). In conclusion, to the best of our knowledge, this is the first time that BAP1 staining has been studied in uveal melanoma in a Spanish community. We believe that this technique should become routine in the pathological examination of uveal melanoma in order to allow adequate classification of patients and to establish an individual follow-up plan.
format	article
author	Laura Tabuenca Del Barrio Luiz Miguel Nova-Camacho Alicia Zubicoa Enériz Iñigo Martínez de Espronceda Ezquerro Alicia Córdoba Iturriagagoitia Enrique Borque Rodríguez-Maimón Alfredo García-Layana
author_facet	Laura Tabuenca Del Barrio Luiz Miguel Nova-Camacho Alicia Zubicoa Enériz Iñigo Martínez de Espronceda Ezquerro Alicia Córdoba Iturriagagoitia Enrique Borque Rodríguez-Maimón Alfredo García-Layana
author_sort	Laura Tabuenca Del Barrio
title	Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain
title_short	Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain
title_full	Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain
title_fullStr	Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain
title_full_unstemmed	Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain
title_sort	prognostic factor utility of bap1 immunohistochemistry in uveal melanoma: a single center study in spain
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d4a6473c3b58421ca6e9828f168ecf99
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Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain

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