Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores

During metaphase, k-fibre microtubules exert force on kinetochores, but there are also non-kinetochore microtubules close to kinetochores without a known function. Here the authors show that these microtubules, which they call bridging fibres, balance interkinetochore tension by bridging sister k-fi...

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Autores principales: Janko Kajtez, Anastasia Solomatina, Maja Novak, Bruno Polak, Kruno Vukušić, Jonas Rüdiger, Gheorghe Cojoc, Ana Milas, Ivana Šumanovac Šestak, Patrik Risteski, Federica Tavano, Anna H. Klemm, Emanuele Roscioli, Julie Welburn, Daniela Cimini, Matko Glunčić, Nenad Pavin, Iva M. Tolić
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/d4a8786484cf46a7a667bff22a510f7a
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Sumario:During metaphase, k-fibre microtubules exert force on kinetochores, but there are also non-kinetochore microtubules close to kinetochores without a known function. Here the authors show that these microtubules, which they call bridging fibres, balance interkinetochore tension by bridging sister k-fibres.