TRPV1 activity and substance P release are required for corneal cold nociception

The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.

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Autores principales:	Fengxian Li, Weishan Yang, Haowu Jiang, Changxiong Guo, Andrew J. W. Huang, Hongzhen Hu, Qin Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4a8ad404f0d41f385e2f421e1c4bb80
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spelling	oai:doaj.org-article:d4a8ad404f0d41f385e2f421e1c4bb802021-12-02T15:35:05ZTRPV1 activity and substance P release are required for corneal cold nociception10.1038/s41467-019-13536-02041-1723https://doaj.org/article/d4a8ad404f0d41f385e2f421e1c4bb802019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13536-0https://doaj.org/toc/2041-1723The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.Fengxian LiWeishan YangHaowu JiangChangxiong GuoAndrew J. W. HuangHongzhen HuQin LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fengxian Li Weishan Yang Haowu Jiang Changxiong Guo Andrew J. W. Huang Hongzhen Hu Qin Liu TRPV1 activity and substance P release are required for corneal cold nociception
description	The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.
format	article
author	Fengxian Li Weishan Yang Haowu Jiang Changxiong Guo Andrew J. W. Huang Hongzhen Hu Qin Liu
author_facet	Fengxian Li Weishan Yang Haowu Jiang Changxiong Guo Andrew J. W. Huang Hongzhen Hu Qin Liu
author_sort	Fengxian Li
title	TRPV1 activity and substance P release are required for corneal cold nociception
title_short	TRPV1 activity and substance P release are required for corneal cold nociception
title_full	TRPV1 activity and substance P release are required for corneal cold nociception
title_fullStr	TRPV1 activity and substance P release are required for corneal cold nociception
title_full_unstemmed	TRPV1 activity and substance P release are required for corneal cold nociception
title_sort	trpv1 activity and substance p release are required for corneal cold nociception
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d4a8ad404f0d41f385e2f421e1c4bb80
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TRPV1 activity and substance P release are required for corneal cold nociception

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