Impact of short-term antiretroviral therapy (START) on some fibrinolytic markers in HIV-infected Nigerian adults: preliminary findings from the START study

Zaccheaus A Jeremiah1, Yetunde Obazee2, Godwin R Okogun3, Teddy C Adias4, Osaro Mgbere5,6, Ekere J Essien61Hematology and Blood Transfusion Science Unit, Department of Medical Laboratory Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, 2General Hospita...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jeremiah ZA, Obazee Y, Okogun GR, Adias TC, Mgbere O, Essien EJ
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://doaj.org/article/d4ab3a6486184bd5bdc364044e510a6d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d4ab3a6486184bd5bdc364044e510a6d
record_format dspace
spelling oai:doaj.org-article:d4ab3a6486184bd5bdc364044e510a6d2021-12-02T05:00:48ZImpact of short-term antiretroviral therapy (START) on some fibrinolytic markers in HIV-infected Nigerian adults: preliminary findings from the START study1179-1373https://doaj.org/article/d4ab3a6486184bd5bdc364044e510a6d2012-07-01T00:00:00Zhttp://www.dovepress.com/impact-of-short-term-antiretroviral-therapy-start-on-some-fibrinolytic-a10347https://doaj.org/toc/1179-1373Zaccheaus A Jeremiah1, Yetunde Obazee2, Godwin R Okogun3, Teddy C Adias4, Osaro Mgbere5,6, Ekere J Essien61Hematology and Blood Transfusion Science Unit, Department of Medical Laboratory Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, 2General Hospital, Maitama District, Abuja, Federal Capital Territory, 3Department of Medical Laboratory Science, Ambrose Ali University, Ekpoma, Edo State, Nigeria; 4College of Health Technology, Bayelsa State, Nigeria; 5Houston Department of Health and Human Services, 6Institute of Community Health, University of Houston, Texas Medical Center, Houston, TX, USABackground: Derangement in fibrinolytic markers can result in thrombosis and cardiovascular problems. Antiretroviral therapy (ART) has been reported to affect the levels of these markers. It is unclear how long a patient can be exposed to ART before the effect of the drugs on the fibrinolytic markers becomes noticeable; this short-term antiretroviral therapy (START) study aimed to answer this question.Methods: Twenty human immunodeficiency virus (HIV)-positive subjects on ART and 20 controls (non-ART) were progressively monitored for three months. CD4 T-cell count was determined while D-dimer, t-PA, and PAI-1 parameters were determined.Results: CD4 T-cell count increased from 192 µL/mL at baseline to 323 µL/mL at month 3 among patients on ART. D-dimer concentrations decreased from 301.0 µL/mL at baseline to 172.0 µL/mL at month 2, then increased to 226.0 µL/mL at the end of the third month. The median baseline concentration of PAI-1 at the beginning of therapy was 14.0 µg/mL, which increased progressively to 18.2 µg/mL at the end of the third month. The baseline concentration of t-PA at the beginning of therapy was 5.15 µg/mL. This progressively declined to 1.10 µg/mL at the end of the first month and reached 1.45 µg/mL and 1.5 µg/mL at the end of the second and third months, respectively. D-dimer was positively and significantly correlated with CD4 cell counts in both AIDs-associated retrovirus (ARV) and non-ARV patients (r = –0.304, P < 0.01 vs r = –0.477, P < 0.001). t-PA was negatively correlated with CD4 T-lymphocytes in those undergoing ART (r = –0.294, P < 0.01).Conclusion: A progressive increase in PAI-1 and steady decline in t-PA concentrations within 3 months of commencement of ART could predispose patients to thrombotic disorders earlier than is expected. Pre-thrombotic assessment during therapy is therefore advocated.Keywords: fibrinolytic markers, D-dimer, t-PA, PAI-1, START studyJeremiah ZAObazee YOkogun GRAdias TCMgbere OEssien EJDove Medical PressarticleImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol 2012, Iss default, Pp 87-94 (2012)
institution DOAJ
collection DOAJ
language EN
topic Immunologic diseases. Allergy
RC581-607
spellingShingle Immunologic diseases. Allergy
RC581-607
Jeremiah ZA
Obazee Y
Okogun GR
Adias TC
Mgbere O
Essien EJ
Impact of short-term antiretroviral therapy (START) on some fibrinolytic markers in HIV-infected Nigerian adults: preliminary findings from the START study
description Zaccheaus A Jeremiah1, Yetunde Obazee2, Godwin R Okogun3, Teddy C Adias4, Osaro Mgbere5,6, Ekere J Essien61Hematology and Blood Transfusion Science Unit, Department of Medical Laboratory Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, 2General Hospital, Maitama District, Abuja, Federal Capital Territory, 3Department of Medical Laboratory Science, Ambrose Ali University, Ekpoma, Edo State, Nigeria; 4College of Health Technology, Bayelsa State, Nigeria; 5Houston Department of Health and Human Services, 6Institute of Community Health, University of Houston, Texas Medical Center, Houston, TX, USABackground: Derangement in fibrinolytic markers can result in thrombosis and cardiovascular problems. Antiretroviral therapy (ART) has been reported to affect the levels of these markers. It is unclear how long a patient can be exposed to ART before the effect of the drugs on the fibrinolytic markers becomes noticeable; this short-term antiretroviral therapy (START) study aimed to answer this question.Methods: Twenty human immunodeficiency virus (HIV)-positive subjects on ART and 20 controls (non-ART) were progressively monitored for three months. CD4 T-cell count was determined while D-dimer, t-PA, and PAI-1 parameters were determined.Results: CD4 T-cell count increased from 192 µL/mL at baseline to 323 µL/mL at month 3 among patients on ART. D-dimer concentrations decreased from 301.0 µL/mL at baseline to 172.0 µL/mL at month 2, then increased to 226.0 µL/mL at the end of the third month. The median baseline concentration of PAI-1 at the beginning of therapy was 14.0 µg/mL, which increased progressively to 18.2 µg/mL at the end of the third month. The baseline concentration of t-PA at the beginning of therapy was 5.15 µg/mL. This progressively declined to 1.10 µg/mL at the end of the first month and reached 1.45 µg/mL and 1.5 µg/mL at the end of the second and third months, respectively. D-dimer was positively and significantly correlated with CD4 cell counts in both AIDs-associated retrovirus (ARV) and non-ARV patients (r = –0.304, P < 0.01 vs r = –0.477, P < 0.001). t-PA was negatively correlated with CD4 T-lymphocytes in those undergoing ART (r = –0.294, P < 0.01).Conclusion: A progressive increase in PAI-1 and steady decline in t-PA concentrations within 3 months of commencement of ART could predispose patients to thrombotic disorders earlier than is expected. Pre-thrombotic assessment during therapy is therefore advocated.Keywords: fibrinolytic markers, D-dimer, t-PA, PAI-1, START study
format article
author Jeremiah ZA
Obazee Y
Okogun GR
Adias TC
Mgbere O
Essien EJ
author_facet Jeremiah ZA
Obazee Y
Okogun GR
Adias TC
Mgbere O
Essien EJ
author_sort Jeremiah ZA
title Impact of short-term antiretroviral therapy (START) on some fibrinolytic markers in HIV-infected Nigerian adults: preliminary findings from the START study
title_short Impact of short-term antiretroviral therapy (START) on some fibrinolytic markers in HIV-infected Nigerian adults: preliminary findings from the START study
title_full Impact of short-term antiretroviral therapy (START) on some fibrinolytic markers in HIV-infected Nigerian adults: preliminary findings from the START study
title_fullStr Impact of short-term antiretroviral therapy (START) on some fibrinolytic markers in HIV-infected Nigerian adults: preliminary findings from the START study
title_full_unstemmed Impact of short-term antiretroviral therapy (START) on some fibrinolytic markers in HIV-infected Nigerian adults: preliminary findings from the START study
title_sort impact of short-term antiretroviral therapy (start) on some fibrinolytic markers in hiv-infected nigerian adults: preliminary findings from the start study
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/d4ab3a6486184bd5bdc364044e510a6d
work_keys_str_mv AT jeremiahza impactofshorttermantiretroviraltherapystartonsomefibrinolyticmarkersinhivinfectednigerianadultspreliminaryfindingsfromthestartstudy
AT obazeey impactofshorttermantiretroviraltherapystartonsomefibrinolyticmarkersinhivinfectednigerianadultspreliminaryfindingsfromthestartstudy
AT okogungr impactofshorttermantiretroviraltherapystartonsomefibrinolyticmarkersinhivinfectednigerianadultspreliminaryfindingsfromthestartstudy
AT adiastc impactofshorttermantiretroviraltherapystartonsomefibrinolyticmarkersinhivinfectednigerianadultspreliminaryfindingsfromthestartstudy
AT mgbereo impactofshorttermantiretroviraltherapystartonsomefibrinolyticmarkersinhivinfectednigerianadultspreliminaryfindingsfromthestartstudy
AT essienej impactofshorttermantiretroviraltherapystartonsomefibrinolyticmarkersinhivinfectednigerianadultspreliminaryfindingsfromthestartstudy
_version_ 1718400857226084352