Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Chimeric antigen receptor (CAR)-based therapy for the treatment of liver cancer represents a promising therapeutic strategy. Here the authors show that CD147-targeting CAR-NK or CAR-T can induce anti-tumor activity against hepatocellular carcinoma in vitro and in vivo.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hsiang-chi Tseng, Wei Xiong, Saiaditya Badeti, Yan Yang, Minh Ma, Ting Liu, Carlos A. Ramos, Gianpietro Dotti, Luke Fritzky, Jie-gen Jiang, Qing Yi, James Guarrera, Wei-Xing Zong, Chen Liu, Dongfang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4aefc73f7c342c4befc39c05ef9b986
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d4aefc73f7c342c4befc39c05ef9b986
record_format	dspace
spelling	oai:doaj.org-article:d4aefc73f7c342c4befc39c05ef9b9862021-12-02T18:14:41ZEfficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma10.1038/s41467-020-18444-22041-1723https://doaj.org/article/d4aefc73f7c342c4befc39c05ef9b9862020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18444-2https://doaj.org/toc/2041-1723Chimeric antigen receptor (CAR)-based therapy for the treatment of liver cancer represents a promising therapeutic strategy. Here the authors show that CD147-targeting CAR-NK or CAR-T can induce anti-tumor activity against hepatocellular carcinoma in vitro and in vivo.Hsiang-chi TsengWei XiongSaiaditya BadetiYan YangMinh MaTing LiuCarlos A. RamosGianpietro DottiLuke FritzkyJie-gen JiangQing YiJames GuarreraWei-Xing ZongChen LiuDongfang LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hsiang-chi Tseng Wei Xiong Saiaditya Badeti Yan Yang Minh Ma Ting Liu Carlos A. Ramos Gianpietro Dotti Luke Fritzky Jie-gen Jiang Qing Yi James Guarrera Wei-Xing Zong Chen Liu Dongfang Liu Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
description	Chimeric antigen receptor (CAR)-based therapy for the treatment of liver cancer represents a promising therapeutic strategy. Here the authors show that CD147-targeting CAR-NK or CAR-T can induce anti-tumor activity against hepatocellular carcinoma in vitro and in vivo.
format	article
author	Hsiang-chi Tseng Wei Xiong Saiaditya Badeti Yan Yang Minh Ma Ting Liu Carlos A. Ramos Gianpietro Dotti Luke Fritzky Jie-gen Jiang Qing Yi James Guarrera Wei-Xing Zong Chen Liu Dongfang Liu
author_facet	Hsiang-chi Tseng Wei Xiong Saiaditya Badeti Yan Yang Minh Ma Ting Liu Carlos A. Ramos Gianpietro Dotti Luke Fritzky Jie-gen Jiang Qing Yi James Guarrera Wei-Xing Zong Chen Liu Dongfang Liu
author_sort	Hsiang-chi Tseng
title	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_short	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_full	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_fullStr	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_full_unstemmed	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_sort	efficacy of anti-cd147 chimeric antigen receptors targeting hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d4aefc73f7c342c4befc39c05ef9b986
work_keys_str_mv	AT hsiangchitseng efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT weixiong efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT saiadityabadeti efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT yanyang efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT minhma efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT tingliu efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT carlosaramos efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT gianpietrodotti efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT lukefritzky efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT jiegenjiang efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT qingyi efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT jamesguarrera efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT weixingzong efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT chenliu efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma AT dongfangliu efficacyofanticd147chimericantigenreceptorstargetinghepatocellularcarcinoma
_version_	1718378423518232576

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Ejemplares similares