A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity

High or multiple doses of macrolide antibiotics, when given early in life, can perturb the metabolic and immunological development of lab mice. Here, Ruiz et al. show that even a single macrolide course, given early in life, leads to long-lasting changes in the gut microbiota and immune system of mi...

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Autores principales: Victoria E. Ruiz, Thomas Battaglia, Zachary D. Kurtz, Luc Bijnens, Amy Ou, Isak Engstrand, Xuhui Zheng, Tadasu Iizumi, Briana J. Mullins, Christian L. Müller, Ken Cadwell, Richard Bonneau, Guillermo I. Perez-Perez, Martin J. Blaser
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d4b11426675d407594f768ad99b19727
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Sumario:High or multiple doses of macrolide antibiotics, when given early in life, can perturb the metabolic and immunological development of lab mice. Here, Ruiz et al. show that even a single macrolide course, given early in life, leads to long-lasting changes in the gut microbiota and immune system of mice.