Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation

(1) Background: Angiotensin II type I receptor antibodies (AT1R-Ab) represent a topic of interest in kidney transplantation (KT). Data regarding the risk factors associated with de novo AT1R-Ab development are lacking. Our goal was to identify the incidence of de novo AT1R-Ab at 1 year after KT and...

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Autores principales:	Bogdan Marian Sorohan, Ioanel Sinescu, Dorina Tacu, Cristina Bucșa, Corina Țincu, Bogdan Obrișcă, Andreea Berechet, Ileana Constantinescu, Ion Mărunțelu, Gener Ismail, Cătălin Baston
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	kidney transplant angiotensin II type 1 receptor antibody immunosuppression induction maintenance de novo Medicine R
Acceso en línea:	https://doaj.org/article/d4b358beca374b73b158c3420998b115
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spelling	oai:doaj.org-article:d4b358beca374b73b158c3420998b1152021-11-25T18:02:22ZImmunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation10.3390/jcm102253902077-0383https://doaj.org/article/d4b358beca374b73b158c3420998b1152021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5390https://doaj.org/toc/2077-0383(1) Background: Angiotensin II type I receptor antibodies (AT1R-Ab) represent a topic of interest in kidney transplantation (KT). Data regarding the risk factors associated with de novo AT1R-Ab development are lacking. Our goal was to identify the incidence of de novo AT1R-Ab at 1 year after KT and to evaluate the risk factors associated with their formation. (2) Methods: We conducted a prospective cohort study on 56 adult patients, transplanted between 2018 and 2019. Recipient, donor, transplant, treatment, and complications data were assessed. A threshold of >10 U/mL was used for AT1R-Ab detection. (3) Results: De novo AT1R-Ab were observed in 12 out of 56 KT recipients (21.4%). The median value AT1R-Ab in the study cohort was 8.5 U/mL (inter quartile range: 6.8–10.4) and 15.6 U/mL (10.8–19.8) in the positive group. By multivariate logistic regression analysis, induction immunosuppression with anti-thymocyte globulin (OR = 7.20, 95% CI: 1.30–39.65, <i>p</i> = 0.02), maintenance immunosuppression with immediate-release tacrolimus (OR = 6.20, 95% CI: 1.16–41.51, <i>p</i> = 0.03), and mean tacrolimus trough level (OR = 2.36, 95% CI: 1.14–4.85, <i>p</i> = 0.01) were independent risk factors for de novo AT1R-Ab at 1 year after KT. (4) Conclusions: De novo AT1R-Ab development at 1 year after KT is significantly influenced by the type of induction and maintenance immunosuppression.Bogdan Marian SorohanIoanel SinescuDorina TacuCristina BucșaCorina ȚincuBogdan ObrișcăAndreea BerechetIleana ConstantinescuIon MărunțeluGener IsmailCătălin BastonMDPI AGarticlekidney transplantangiotensin II type 1 receptor antibodyimmunosuppressioninductionmaintenancede novoMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5390, p 5390 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	kidney transplant angiotensin II type 1 receptor antibody immunosuppression induction maintenance de novo Medicine R
spellingShingle	kidney transplant angiotensin II type 1 receptor antibody immunosuppression induction maintenance de novo Medicine R Bogdan Marian Sorohan Ioanel Sinescu Dorina Tacu Cristina Bucșa Corina Țincu Bogdan Obrișcă Andreea Berechet Ileana Constantinescu Ion Mărunțelu Gener Ismail Cătălin Baston Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation
description	(1) Background: Angiotensin II type I receptor antibodies (AT1R-Ab) represent a topic of interest in kidney transplantation (KT). Data regarding the risk factors associated with de novo AT1R-Ab development are lacking. Our goal was to identify the incidence of de novo AT1R-Ab at 1 year after KT and to evaluate the risk factors associated with their formation. (2) Methods: We conducted a prospective cohort study on 56 adult patients, transplanted between 2018 and 2019. Recipient, donor, transplant, treatment, and complications data were assessed. A threshold of >10 U/mL was used for AT1R-Ab detection. (3) Results: De novo AT1R-Ab were observed in 12 out of 56 KT recipients (21.4%). The median value AT1R-Ab in the study cohort was 8.5 U/mL (inter quartile range: 6.8–10.4) and 15.6 U/mL (10.8–19.8) in the positive group. By multivariate logistic regression analysis, induction immunosuppression with anti-thymocyte globulin (OR = 7.20, 95% CI: 1.30–39.65, <i>p</i> = 0.02), maintenance immunosuppression with immediate-release tacrolimus (OR = 6.20, 95% CI: 1.16–41.51, <i>p</i> = 0.03), and mean tacrolimus trough level (OR = 2.36, 95% CI: 1.14–4.85, <i>p</i> = 0.01) were independent risk factors for de novo AT1R-Ab at 1 year after KT. (4) Conclusions: De novo AT1R-Ab development at 1 year after KT is significantly influenced by the type of induction and maintenance immunosuppression.
format	article
author	Bogdan Marian Sorohan Ioanel Sinescu Dorina Tacu Cristina Bucșa Corina Țincu Bogdan Obrișcă Andreea Berechet Ileana Constantinescu Ion Mărunțelu Gener Ismail Cătălin Baston
author_facet	Bogdan Marian Sorohan Ioanel Sinescu Dorina Tacu Cristina Bucșa Corina Țincu Bogdan Obrișcă Andreea Berechet Ileana Constantinescu Ion Mărunțelu Gener Ismail Cătălin Baston
author_sort	Bogdan Marian Sorohan
title	Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation
title_short	Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation
title_full	Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation
title_fullStr	Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation
title_full_unstemmed	Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation
title_sort	immunosuppression as a risk factor for de novo angiotensin ii type receptor antibodies development after kidney transplantation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d4b358beca374b73b158c3420998b115
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Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation

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