Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma

Surgery is still the first-line treatment for multiple solid cancers. However, recurrence is a common issue, especially when dealing with aggressive tumors or tumors that are difficult to completely remove due to their location. Getting clear surgical margins can be challenging, but treatment strate...

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Autores principales:	Marina Simón, Jesper Tranekjær Jørgensen, Fredrik Melander, Thomas Lars Andresen, Anders Christensen, Andreas Kjaer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	photothermal therapy (PTT) surgery fibrosarcoma magnetic resonance imaging (MRI) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d4b3f517877e411fb8f8754653d8aa50
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spelling	oai:doaj.org-article:d4b3f517877e411fb8f8754653d8aa502021-11-25T17:04:25ZPhotothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma10.3390/cancers132258202072-6694https://doaj.org/article/d4b3f517877e411fb8f8754653d8aa502021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5820https://doaj.org/toc/2072-6694Surgery is still the first-line treatment for multiple solid cancers. However, recurrence is a common issue, especially when dealing with aggressive tumors or tumors that are difficult to completely remove due to their location. Getting clear surgical margins can be challenging, but treatment strategies combining surgery with other anti-cancer therapies can potentially improve the outcome. Photothermal therapy (PTT) is a technique that relies on photoabsorbing agents, such as gold nanoparticles, to transform light into local hyperthermia. This technique can be used to ablate tumor tissue where the photoabsorbing agent accumulates, sparing healthy surrounding tissue. In this study, we examined the potential of gold nanoparticle-based PTT as an adjuvant treatment to surgery in a mouse model of human fibrosarcoma. For this we performed subtotal tumor resection to mimic a clinical situation where total tumor removal is not achieved, and subsequent PTT was applied on the surgical field. Our results showed that animals undergoing adjuvant PTT after surgery presented sustained delayed tumor growth and improved survival when compared to animals that only underwent surgery. We believe that these findings show the potential of PTT as an adjuvant method to traditional tumor surgery and could pave way to more personalized treatment options.Marina SimónJesper Tranekjær JørgensenFredrik MelanderThomas Lars AndresenAnders ChristensenAndreas KjaerMDPI AGarticlephotothermal therapy (PTT)surgeryfibrosarcomamagnetic resonance imaging (MRI)Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5820, p 5820 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	photothermal therapy (PTT) surgery fibrosarcoma magnetic resonance imaging (MRI) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	photothermal therapy (PTT) surgery fibrosarcoma magnetic resonance imaging (MRI) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marina Simón Jesper Tranekjær Jørgensen Fredrik Melander Thomas Lars Andresen Anders Christensen Andreas Kjaer Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma
description	Surgery is still the first-line treatment for multiple solid cancers. However, recurrence is a common issue, especially when dealing with aggressive tumors or tumors that are difficult to completely remove due to their location. Getting clear surgical margins can be challenging, but treatment strategies combining surgery with other anti-cancer therapies can potentially improve the outcome. Photothermal therapy (PTT) is a technique that relies on photoabsorbing agents, such as gold nanoparticles, to transform light into local hyperthermia. This technique can be used to ablate tumor tissue where the photoabsorbing agent accumulates, sparing healthy surrounding tissue. In this study, we examined the potential of gold nanoparticle-based PTT as an adjuvant treatment to surgery in a mouse model of human fibrosarcoma. For this we performed subtotal tumor resection to mimic a clinical situation where total tumor removal is not achieved, and subsequent PTT was applied on the surgical field. Our results showed that animals undergoing adjuvant PTT after surgery presented sustained delayed tumor growth and improved survival when compared to animals that only underwent surgery. We believe that these findings show the potential of PTT as an adjuvant method to traditional tumor surgery and could pave way to more personalized treatment options.
format	article
author	Marina Simón Jesper Tranekjær Jørgensen Fredrik Melander Thomas Lars Andresen Anders Christensen Andreas Kjaer
author_facet	Marina Simón Jesper Tranekjær Jørgensen Fredrik Melander Thomas Lars Andresen Anders Christensen Andreas Kjaer
author_sort	Marina Simón
title	Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma
title_short	Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma
title_full	Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma
title_fullStr	Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma
title_full_unstemmed	Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma
title_sort	photothermal therapy as adjuvant to surgery in an orthotopic mouse model of human fibrosarcoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d4b3f517877e411fb8f8754653d8aa50
work_keys_str_mv	AT marinasimon photothermaltherapyasadjuvanttosurgeryinanorthotopicmousemodelofhumanfibrosarcoma AT jespertranekjærjørgensen photothermaltherapyasadjuvanttosurgeryinanorthotopicmousemodelofhumanfibrosarcoma AT fredrikmelander photothermaltherapyasadjuvanttosurgeryinanorthotopicmousemodelofhumanfibrosarcoma AT thomaslarsandresen photothermaltherapyasadjuvanttosurgeryinanorthotopicmousemodelofhumanfibrosarcoma AT anderschristensen photothermaltherapyasadjuvanttosurgeryinanorthotopicmousemodelofhumanfibrosarcoma AT andreaskjaer photothermaltherapyasadjuvanttosurgeryinanorthotopicmousemodelofhumanfibrosarcoma
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Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma

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