Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer

The mechanism of tumor progression robustly promoted by co-existing BRAF V600E and TERT promoter mutations is not known. Here, the authors show a mechanism of mutant TERT activation by BRAF V600E and MAPK pathways in which FOS, as a transcription factor of the GABPB promoter, functionally links the...

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Autores principales:	Rengyun Liu, Tao Zhang, Guangwu Zhu, Mingzhao Xing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4b548257fc845b2b87139be67a0bbf8
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spelling	oai:doaj.org-article:d4b548257fc845b2b87139be67a0bbf82021-12-02T17:31:16ZRegulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer10.1038/s41467-018-03033-12041-1723https://doaj.org/article/d4b548257fc845b2b87139be67a0bbf82018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03033-1https://doaj.org/toc/2041-1723The mechanism of tumor progression robustly promoted by co-existing BRAF V600E and TERT promoter mutations is not known. Here, the authors show a mechanism of mutant TERT activation by BRAF V600E and MAPK pathways in which FOS, as a transcription factor of the GABPB promoter, functionally links the two oncogenes.Rengyun LiuTao ZhangGuangwu ZhuMingzhao XingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rengyun Liu Tao Zhang Guangwu Zhu Mingzhao Xing Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
description	The mechanism of tumor progression robustly promoted by co-existing BRAF V600E and TERT promoter mutations is not known. Here, the authors show a mechanism of mutant TERT activation by BRAF V600E and MAPK pathways in which FOS, as a transcription factor of the GABPB promoter, functionally links the two oncogenes.
format	article
author	Rengyun Liu Tao Zhang Guangwu Zhu Mingzhao Xing
author_facet	Rengyun Liu Tao Zhang Guangwu Zhu Mingzhao Xing
author_sort	Rengyun Liu
title	Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
title_short	Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
title_full	Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
title_fullStr	Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
title_full_unstemmed	Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
title_sort	regulation of mutant tert by braf v600e/map kinase pathway through fos/gabp in human cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d4b548257fc845b2b87139be67a0bbf8
work_keys_str_mv	AT rengyunliu regulationofmutanttertbybrafv600emapkinasepathwaythroughfosgabpinhumancancer AT taozhang regulationofmutanttertbybrafv600emapkinasepathwaythroughfosgabpinhumancancer AT guangwuzhu regulationofmutanttertbybrafv600emapkinasepathwaythroughfosgabpinhumancancer AT mingzhaoxing regulationofmutanttertbybrafv600emapkinasepathwaythroughfosgabpinhumancancer
_version_	1718380702713511936

Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer

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