Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance

Chronic stress is a risk factor for mood disorders, yet the molecular and circuit mechanisms of stress-induced changes are not well understood. Here, the authors report the role of the transcription factor ΔFosB in driving activity changes in response to stress in glutamatergic neurons in the ventra...

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Autores principales:	Andrew L. Eagle, Claire E. Manning, Elizabeth S. Williams, Ryan M. Bastle, Paula A. Gajewski, Amber Garrison, Alexis J. Wirtz, Seda Akguen, Katie Brandel-Ankrapp, Wilson Endege, Frederick M. Boyce, Yoshinori N. Ohnishi, Michelle Mazei-Robison, Ian Maze, Rachel L. Neve, Alfred J. Robison
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4b95067e74845b094227a1938275611
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spelling	oai:doaj.org-article:d4b95067e74845b094227a19382756112021-12-02T17:42:11ZCircuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance10.1038/s41467-020-17825-x2041-1723https://doaj.org/article/d4b95067e74845b094227a19382756112020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17825-xhttps://doaj.org/toc/2041-1723Chronic stress is a risk factor for mood disorders, yet the molecular and circuit mechanisms of stress-induced changes are not well understood. Here, the authors report the role of the transcription factor ΔFosB in driving activity changes in response to stress in glutamatergic neurons in the ventral hippocampus that project to nucleus accumben.Andrew L. EagleClaire E. ManningElizabeth S. WilliamsRyan M. BastlePaula A. GajewskiAmber GarrisonAlexis J. WirtzSeda AkguenKatie Brandel-AnkrappWilson EndegeFrederick M. BoyceYoshinori N. OhnishiMichelle Mazei-RobisonIan MazeRachel L. NeveAlfred J. RobisonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew L. Eagle Claire E. Manning Elizabeth S. Williams Ryan M. Bastle Paula A. Gajewski Amber Garrison Alexis J. Wirtz Seda Akguen Katie Brandel-Ankrapp Wilson Endege Frederick M. Boyce Yoshinori N. Ohnishi Michelle Mazei-Robison Ian Maze Rachel L. Neve Alfred J. Robison Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance
description	Chronic stress is a risk factor for mood disorders, yet the molecular and circuit mechanisms of stress-induced changes are not well understood. Here, the authors report the role of the transcription factor ΔFosB in driving activity changes in response to stress in glutamatergic neurons in the ventral hippocampus that project to nucleus accumben.
format	article
author	Andrew L. Eagle Claire E. Manning Elizabeth S. Williams Ryan M. Bastle Paula A. Gajewski Amber Garrison Alexis J. Wirtz Seda Akguen Katie Brandel-Ankrapp Wilson Endege Frederick M. Boyce Yoshinori N. Ohnishi Michelle Mazei-Robison Ian Maze Rachel L. Neve Alfred J. Robison
author_facet	Andrew L. Eagle Claire E. Manning Elizabeth S. Williams Ryan M. Bastle Paula A. Gajewski Amber Garrison Alexis J. Wirtz Seda Akguen Katie Brandel-Ankrapp Wilson Endege Frederick M. Boyce Yoshinori N. Ohnishi Michelle Mazei-Robison Ian Maze Rachel L. Neve Alfred J. Robison
author_sort	Andrew L. Eagle
title	Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance
title_short	Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance
title_full	Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance
title_fullStr	Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance
title_full_unstemmed	Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance
title_sort	circuit-specific hippocampal δfosb underlies resilience to stress-induced social avoidance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d4b95067e74845b094227a1938275611
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Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance

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