Possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae

Aim. To increase the effectiveness of complex treatment of women with intrauterine synechiae (IS) through intrauterine administration of platelet-rich plasma (PRP). Materials and methods. The authors studied the complex treatment results of 60 women with second and third degree intrauterine synec...

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Autores principales:	Sergey A. Martynov, Leyla V. Adamyan, Alek S. Arakelyan, Tatyana A. Fyodorova, Oksana A. Bystrykh
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	intrauterine synechiae asherman syndrome platelet-rich plasma Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/d4b9a9db51d643aba2547ff3c1c0b246
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spelling	oai:doaj.org-article:d4b9a9db51d643aba2547ff3c1c0b2462021-12-02T19:22:24ZPossibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae2079-56962079-583110.26442/20795696.2021.3.200878https://doaj.org/article/d4b9a9db51d643aba2547ff3c1c0b2462021-08-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/76151/56745https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To increase the effectiveness of complex treatment of women with intrauterine synechiae (IS) through intrauterine administration of platelet-rich plasma (PRP). Materials and methods. The authors studied the complex treatment results of 60 women with second and third degree intrauterine synechiae: 20 patients in the active treatment group, after hysteroscopic destruction of intrauterine synechiae, underwent intraoperative subendometrial administration of PRP followed by irrigating the uterine cavity with PRP on the 2nd and 3rd days after the operation, along with complex postoperative treatment (antibacteria and cyclic hormone therapy, physiotherapy); 40 patients in the comparison group underwent only complex postoperative treatment without PRP administration. The authors conducted comparative assessments of menstrual function, endometrial thickness and uterine cavity during check-up hysteroscopy procedure. Results. Two months after the treatment, a statistically more significant increase in the thickness of endometrial tissue was found with the use of PRP compared with patients treated without PRP (p=0.03 and 0.04). Statistically more significant changes in the state of the uterine cavity were revealed when using PRP in the group of patients with the second-degree process severity (p=0.00005), while in patients with the third-degree process severity there were no statistically significant differences identified depending on the method of treatment used. The authors confirm high safety and reliability of the method as well as no adverse reactions to parenteral and intracavitary administration of autologous PRP. Conclusion. The study confirmed applicability and prospects of using PRP as a stage in complex treatment of IS patients.Sergey A. MartynovLeyla V. AdamyanAlek S. ArakelyanTatyana A. FyodorovaOksana A. BystrykhIP Berlin A.V. articleintrauterine synechiaeasherman syndromeplatelet-rich plasmaGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 3, Pp 250-254 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	intrauterine synechiae asherman syndrome platelet-rich plasma Gynecology and obstetrics RG1-991
spellingShingle	intrauterine synechiae asherman syndrome platelet-rich plasma Gynecology and obstetrics RG1-991 Sergey A. Martynov Leyla V. Adamyan Alek S. Arakelyan Tatyana A. Fyodorova Oksana A. Bystrykh Possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae
description	Aim. To increase the effectiveness of complex treatment of women with intrauterine synechiae (IS) through intrauterine administration of platelet-rich plasma (PRP). Materials and methods. The authors studied the complex treatment results of 60 women with second and third degree intrauterine synechiae: 20 patients in the active treatment group, after hysteroscopic destruction of intrauterine synechiae, underwent intraoperative subendometrial administration of PRP followed by irrigating the uterine cavity with PRP on the 2nd and 3rd days after the operation, along with complex postoperative treatment (antibacteria and cyclic hormone therapy, physiotherapy); 40 patients in the comparison group underwent only complex postoperative treatment without PRP administration. The authors conducted comparative assessments of menstrual function, endometrial thickness and uterine cavity during check-up hysteroscopy procedure. Results. Two months after the treatment, a statistically more significant increase in the thickness of endometrial tissue was found with the use of PRP compared with patients treated without PRP (p=0.03 and 0.04). Statistically more significant changes in the state of the uterine cavity were revealed when using PRP in the group of patients with the second-degree process severity (p=0.00005), while in patients with the third-degree process severity there were no statistically significant differences identified depending on the method of treatment used. The authors confirm high safety and reliability of the method as well as no adverse reactions to parenteral and intracavitary administration of autologous PRP. Conclusion. The study confirmed applicability and prospects of using PRP as a stage in complex treatment of IS patients.
format	article
author	Sergey A. Martynov Leyla V. Adamyan Alek S. Arakelyan Tatyana A. Fyodorova Oksana A. Bystrykh
author_facet	Sergey A. Martynov Leyla V. Adamyan Alek S. Arakelyan Tatyana A. Fyodorova Oksana A. Bystrykh
author_sort	Sergey A. Martynov
title	Possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae
title_short	Possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae
title_full	Possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae
title_fullStr	Possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae
title_full_unstemmed	Possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae
title_sort	possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/d4b9a9db51d643aba2547ff3c1c0b246
work_keys_str_mv	AT sergeyamartynov possibilitiesofusingplateletrichautoplasminthecomplextreatmentofpatientswithintrauterinesynechiae AT leylavadamyan possibilitiesofusingplateletrichautoplasminthecomplextreatmentofpatientswithintrauterinesynechiae AT aleksarakelyan possibilitiesofusingplateletrichautoplasminthecomplextreatmentofpatientswithintrauterinesynechiae AT tatyanaafyodorova possibilitiesofusingplateletrichautoplasminthecomplextreatmentofpatientswithintrauterinesynechiae AT oksanaabystrykh possibilitiesofusingplateletrichautoplasminthecomplextreatmentofpatientswithintrauterinesynechiae
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Possibilities of using platelet-rich autoplasm in the complex treatment of patients with intrauterine synechiae

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