HIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.

<h4>Background</h4>HIV prevalence and incidence among sexually active women in peri-urban areas of Ladysmith, Edendale, and Pinetown, KwaZulu-Natal, South Africa, were assessed between October 2007 and February 2010 in preparation for vaginal microbicide trials.<h4>Methodology/prin...

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Autores principales:	Annaléne Nel, Zonke Mabude, Jenni Smit, Philip Kotze, Derek Arbuckle, Jian Wu, Neliëtte van Niekerk, Janneke van de Wijgert
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4bcc9baa568413590fd2455062c9f20
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spelling	oai:doaj.org-article:d4bcc9baa568413590fd2455062c9f202021-11-18T07:21:37ZHIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.1932-620310.1371/journal.pone.0035278https://doaj.org/article/d4bcc9baa568413590fd2455062c9f202012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22536364/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>HIV prevalence and incidence among sexually active women in peri-urban areas of Ladysmith, Edendale, and Pinetown, KwaZulu-Natal, South Africa, were assessed between October 2007 and February 2010 in preparation for vaginal microbicide trials.<h4>Methodology/principal findings</h4>Sexually active women 18-35 years, not known to be HIV-positive or pregnant were tested cross-sectionally to determine HIV and pregnancy prevalence (798 in Ladysmith, 1,084 in Edendale, and 891 in Pinetown). Out of these, approximately 300 confirmed non-pregnant, HIV-negative women were subsequently enrolled at each clinical research center (CRC) in a 12-month cohort study with quarterly study visits. Women in the cohort studies were required to use a condom plus a hormonal contraceptive method. HIV prevalence rates in the baseline cross-sectional surveys were high: 42% in Ladysmith, 46% in Edendale and 41% in Pinetown. Around 90% of study participants at each CRC reported one sex partner in the last 3 months, but only 14-30% stated that they were sure that none of their sex partners were HIV-positive. HIV incidence rates based on seroconversions over 12 months were 14.8/100 person-years (PY) (95% CI 9.7, 19.8) in Ladysmith, 6.3/100 PY (95% CI 3.2, 9.4) in Edendale, and 7.2/100 PY (95% CI 3.7, 10.7) in Pinetown. The 12-month pregnancy incidence rates (in the context of high reported contraceptive use) were: 5.7/100 PY (95% CI 2.6, 8.7) in Ladysmith, 3.1/100 PY (95% CI 0.9, 5.2) in Edendale and 6.3/100 PY (95% CI 3.0, 9.6) in Pinetown.<h4>Conclusions/significance</h4>HIV prevalence and incidence remain high in peri-urban areas of KwaZulu-Natal.Annaléne NelZonke MabudeJenni SmitPhilip KotzeDerek ArbuckleJian WuNeliëtte van NiekerkJanneke van de WijgertPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35278 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annaléne Nel Zonke Mabude Jenni Smit Philip Kotze Derek Arbuckle Jian Wu Neliëtte van Niekerk Janneke van de Wijgert HIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.
description	<h4>Background</h4>HIV prevalence and incidence among sexually active women in peri-urban areas of Ladysmith, Edendale, and Pinetown, KwaZulu-Natal, South Africa, were assessed between October 2007 and February 2010 in preparation for vaginal microbicide trials.<h4>Methodology/principal findings</h4>Sexually active women 18-35 years, not known to be HIV-positive or pregnant were tested cross-sectionally to determine HIV and pregnancy prevalence (798 in Ladysmith, 1,084 in Edendale, and 891 in Pinetown). Out of these, approximately 300 confirmed non-pregnant, HIV-negative women were subsequently enrolled at each clinical research center (CRC) in a 12-month cohort study with quarterly study visits. Women in the cohort studies were required to use a condom plus a hormonal contraceptive method. HIV prevalence rates in the baseline cross-sectional surveys were high: 42% in Ladysmith, 46% in Edendale and 41% in Pinetown. Around 90% of study participants at each CRC reported one sex partner in the last 3 months, but only 14-30% stated that they were sure that none of their sex partners were HIV-positive. HIV incidence rates based on seroconversions over 12 months were 14.8/100 person-years (PY) (95% CI 9.7, 19.8) in Ladysmith, 6.3/100 PY (95% CI 3.2, 9.4) in Edendale, and 7.2/100 PY (95% CI 3.7, 10.7) in Pinetown. The 12-month pregnancy incidence rates (in the context of high reported contraceptive use) were: 5.7/100 PY (95% CI 2.6, 8.7) in Ladysmith, 3.1/100 PY (95% CI 0.9, 5.2) in Edendale and 6.3/100 PY (95% CI 3.0, 9.6) in Pinetown.<h4>Conclusions/significance</h4>HIV prevalence and incidence remain high in peri-urban areas of KwaZulu-Natal.
format	article
author	Annaléne Nel Zonke Mabude Jenni Smit Philip Kotze Derek Arbuckle Jian Wu Neliëtte van Niekerk Janneke van de Wijgert
author_facet	Annaléne Nel Zonke Mabude Jenni Smit Philip Kotze Derek Arbuckle Jian Wu Neliëtte van Niekerk Janneke van de Wijgert
author_sort	Annaléne Nel
title	HIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.
title_short	HIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.
title_full	HIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.
title_fullStr	HIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.
title_full_unstemmed	HIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.
title_sort	hiv incidence remains high in kwazulu-natal, south africa: evidence from three districts.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d4bcc9baa568413590fd2455062c9f20
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HIV incidence remains high in KwaZulu-Natal, South Africa: evidence from three districts.

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