Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation

Abstract We developed a method for measuring in vivo venular volumes and the mean systemic filling pressure in the limbs using near-infrared spectroscopy (NIRS). We aimed to validate the NIRS methodology by comparing two independent methods of calculation based on different physiological approaches....

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Autores principales:	Roberto Alberto De Blasi, Stefano Finazzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4c155af86f745e58c033d86a31daf0d
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spelling	oai:doaj.org-article:d4c155af86f745e58c033d86a31daf0d2021-12-02T18:49:23ZValidation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation10.1038/s41598-021-95350-72045-2322https://doaj.org/article/d4c155af86f745e58c033d86a31daf0d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95350-7https://doaj.org/toc/2045-2322Abstract We developed a method for measuring in vivo venular volumes and the mean systemic filling pressure in the limbs using near-infrared spectroscopy (NIRS). We aimed to validate the NIRS methodology by comparing two independent methods of calculation based on different physiological approaches. Pressure–volumes (P–V) curves were recorded following graded venous occlusion on the forearm. Values from a P–V curves analysis model (method 1) were compared with data derived from a resistor-capacitance calculation model (method 2) based on arterial pressure and venous compliance. We tested these methods on 10 healthy participants at rest and during exercise and on 6 severely ill patients. Results from method 1 were comparable with those calculated by method 2. Venular volumes calculated using method 1 correlated linearly with those calculated using method 2 both in participants (R2 = 0.98) and in patients (R2 = 0.94). A good agreement between methods was shown with few values out of the range of ± 1.96 standard deviation. Our findings added mathematical consistency for the NIRS methodology validation in the venular P–V assessment with no flow interruption. Further research will be required to confirm the relevance of the methodology in the clinical setting.Roberto Alberto De BlasiStefano FinazziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roberto Alberto De Blasi Stefano Finazzi Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation
description	Abstract We developed a method for measuring in vivo venular volumes and the mean systemic filling pressure in the limbs using near-infrared spectroscopy (NIRS). We aimed to validate the NIRS methodology by comparing two independent methods of calculation based on different physiological approaches. Pressure–volumes (P–V) curves were recorded following graded venous occlusion on the forearm. Values from a P–V curves analysis model (method 1) were compared with data derived from a resistor-capacitance calculation model (method 2) based on arterial pressure and venous compliance. We tested these methods on 10 healthy participants at rest and during exercise and on 6 severely ill patients. Results from method 1 were comparable with those calculated by method 2. Venular volumes calculated using method 1 correlated linearly with those calculated using method 2 both in participants (R2 = 0.98) and in patients (R2 = 0.94). A good agreement between methods was shown with few values out of the range of ± 1.96 standard deviation. Our findings added mathematical consistency for the NIRS methodology validation in the venular P–V assessment with no flow interruption. Further research will be required to confirm the relevance of the methodology in the clinical setting.
format	article
author	Roberto Alberto De Blasi Stefano Finazzi
author_facet	Roberto Alberto De Blasi Stefano Finazzi
author_sort	Roberto Alberto De Blasi
title	Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation
title_short	Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation
title_full	Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation
title_fullStr	Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation
title_full_unstemmed	Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation
title_sort	validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d4c155af86f745e58c033d86a31daf0d
work_keys_str_mv	AT robertoalbertodeblasi validationofthemeansystemicfillingpressureassessmentwithpreservedarterialbloodflowbycomparingtwomethodsofcalculation AT stefanofinazzi validationofthemeansystemicfillingpressureassessmentwithpreservedarterialbloodflowbycomparingtwomethodsofcalculation
_version_	1718377593104760832

Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation

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