CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

Dormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in breast cancer patients, and promote dormancy in a p...

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Autores principales:	Paulino Tallón de Lara, Héctor Castañón, Marijne Vermeer, Nicolás Núñez, Karina Silina, Bettina Sobottka, Joaquín Urdinez, Virginia Cecconi, Hideo Yagita, Farkhondeh Movahedian Attar, Stefanie Hiltbrunner, Isabelle Glarner, Holger Moch, Sònia Tugues, Burkhard Becher, Maries van den Broek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4c93583ff8e4ff4b53a6a528ca96962
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spelling	oai:doaj.org-article:d4c93583ff8e4ff4b53a6a528ca969622021-12-02T10:44:05ZCD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer10.1038/s41467-021-21045-22041-1723https://doaj.org/article/d4c93583ff8e4ff4b53a6a528ca969622021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21045-2https://doaj.org/toc/2041-1723Dormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in breast cancer patients, and promote dormancy in a preclinical model.Paulino Tallón de LaraHéctor CastañónMarijne VermeerNicolás NúñezKarina SilinaBettina SobottkaJoaquín UrdinezVirginia CecconiHideo YagitaFarkhondeh Movahedian AttarStefanie HiltbrunnerIsabelle GlarnerHolger MochSònia TuguesBurkhard BecherMaries van den BroekNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paulino Tallón de Lara Héctor Castañón Marijne Vermeer Nicolás Núñez Karina Silina Bettina Sobottka Joaquín Urdinez Virginia Cecconi Hideo Yagita Farkhondeh Movahedian Attar Stefanie Hiltbrunner Isabelle Glarner Holger Moch Sònia Tugues Burkhard Becher Maries van den Broek CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
description	Dormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in breast cancer patients, and promote dormancy in a preclinical model.
format	article
author	Paulino Tallón de Lara Héctor Castañón Marijne Vermeer Nicolás Núñez Karina Silina Bettina Sobottka Joaquín Urdinez Virginia Cecconi Hideo Yagita Farkhondeh Movahedian Attar Stefanie Hiltbrunner Isabelle Glarner Holger Moch Sònia Tugues Burkhard Becher Maries van den Broek
author_facet	Paulino Tallón de Lara Héctor Castañón Marijne Vermeer Nicolás Núñez Karina Silina Bettina Sobottka Joaquín Urdinez Virginia Cecconi Hideo Yagita Farkhondeh Movahedian Attar Stefanie Hiltbrunner Isabelle Glarner Holger Moch Sònia Tugues Burkhard Becher Maries van den Broek
author_sort	Paulino Tallón de Lara
title	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_short	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_full	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_fullStr	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_full_unstemmed	CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer
title_sort	cd39+pd-1+cd8+ t cells mediate metastatic dormancy in breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d4c93583ff8e4ff4b53a6a528ca96962
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CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

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