BIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES

Rabies is a neurological disease of a viral nature, leading to death. Rabies virus is an RNA virus that invades the central nervous system, leading to neuronal dysfunction. Timely vaccination can prevent the diseases development. Aim. The article is devoted to immunobiotechnological research aime...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Krasnopolsky Yu. М., Pylypenko D. М.
Formato:	article
Lenguaje:	EN RU UK
Publicado:	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2021
Materias:	immunobiotechnology viral vaccines antirabic vaccine rna virus rabies virus. Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/d4ca7e8cc7f94acbb54df11716dfddf3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d4ca7e8cc7f94acbb54df11716dfddf3
record_format	dspace
spelling	oai:doaj.org-article:d4ca7e8cc7f94acbb54df11716dfddf32021-11-03T17:15:13ZBIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES2410-77512410-776Xhttps://doaj.org/article/d4ca7e8cc7f94acbb54df11716dfddf32021-08-01T00:00:00Zhttp://biotechnology.kiev.ua/images/4_2021/krasnopolsky_4_2021.pdfhttps://doaj.org/toc/2410-7751https://doaj.org/toc/2410-776XRabies is a neurological disease of a viral nature, leading to death. Rabies virus is an RNA virus that invades the central nervous system, leading to neuronal dysfunction. Timely vaccination can prevent the diseases development. Aim. The article is devoted to immunobiotechnological research aimed at creating antirabic vaccines. Results. The history of the antirabic vaccines creation from the first inactivated vaccines obtained from nervous tissue to the cultivation of the virus on animal cell cultures is considered. The article presents commercially available anti-rabies vaccines: their composition, the used rabies virus strains, cell cultures, the methods of inactivation and purification. The technology of producing an anti-rabies vaccine based on a Pitman Moore virus strain and a chicken fibroblast cell culture is presented. The advantages of different vaccine types are considered: live attenuated, peptide, liposomal, RNA vaccines, vaccines based on viral vectors, transgenic plants and reverse genetics methods. Conclusions. The development of biotechnology, immunology and virology makes it possible to improve constantly vaccine preparations, including those against rabies, increasing their effectiveness and safety.Krasnopolsky Yu. М.Pylypenko D. М.National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.articleimmunobiotechnologyviral vaccinesantirabic vaccinerna virusrabies virus.BiotechnologyTP248.13-248.65ENRUUKBiotechnologia Acta, Vol 14, Iss 4, Pp 28-37 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	immunobiotechnology viral vaccines antirabic vaccine rna virus rabies virus. Biotechnology TP248.13-248.65
spellingShingle	immunobiotechnology viral vaccines antirabic vaccine rna virus rabies virus. Biotechnology TP248.13-248.65 Krasnopolsky Yu. М. Pylypenko D. М. BIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES
description	Rabies is a neurological disease of a viral nature, leading to death. Rabies virus is an RNA virus that invades the central nervous system, leading to neuronal dysfunction. Timely vaccination can prevent the diseases development. Aim. The article is devoted to immunobiotechnological research aimed at creating antirabic vaccines. Results. The history of the antirabic vaccines creation from the first inactivated vaccines obtained from nervous tissue to the cultivation of the virus on animal cell cultures is considered. The article presents commercially available anti-rabies vaccines: their composition, the used rabies virus strains, cell cultures, the methods of inactivation and purification. The technology of producing an anti-rabies vaccine based on a Pitman Moore virus strain and a chicken fibroblast cell culture is presented. The advantages of different vaccine types are considered: live attenuated, peptide, liposomal, RNA vaccines, vaccines based on viral vectors, transgenic plants and reverse genetics methods. Conclusions. The development of biotechnology, immunology and virology makes it possible to improve constantly vaccine preparations, including those against rabies, increasing their effectiveness and safety.
format	article
author	Krasnopolsky Yu. М. Pylypenko D. М.
author_facet	Krasnopolsky Yu. М. Pylypenko D. М.
author_sort	Krasnopolsky Yu. М.
title	BIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES
title_short	BIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES
title_full	BIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES
title_fullStr	BIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES
title_full_unstemmed	BIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES
title_sort	biotechnological research in the creation and production of antirabic vaccines
publisher	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
publishDate	2021
url	https://doaj.org/article/d4ca7e8cc7f94acbb54df11716dfddf3
work_keys_str_mv	AT krasnopolskyyum biotechnologicalresearchinthecreationandproductionofantirabicvaccines AT pylypenkodm biotechnologicalresearchinthecreationandproductionofantirabicvaccines
_version_	1718445545244065792

BIOTECHNOLOGICAL RESEARCH IN THE CREATION AND PRODUCTION OF ANTIRABIC VACCINES

Ejemplares similares