Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit melanomagenesis in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Shuyang Chen, Changpeng Han, Xiao Miao, Xin Li, Chengqian Yin, Junrong Zou, Min Liu, Shanshan Li, Lukasz Stawski, Bo Zhu, Qiong Shi, Zhi-Xiang Xu, Chunying Li, Colin R. Goding, Jun Zhou, Rutao Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4cb91d255ff4330b7ffd8d024fa1867
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d4cb91d255ff4330b7ffd8d024fa1867
record_format	dspace
spelling	oai:doaj.org-article:d4cb91d255ff4330b7ffd8d024fa18672021-12-02T14:35:43ZTargeting MC1R depalmitoylation to prevent melanomagenesis in redheads10.1038/s41467-019-08691-32041-1723https://doaj.org/article/d4cb91d255ff4330b7ffd8d024fa18672019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08691-3https://doaj.org/toc/2041-1723Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit melanomagenesis in mice.Shuyang ChenChangpeng HanXiao MiaoXin LiChengqian YinJunrong ZouMin LiuShanshan LiLukasz StawskiBo ZhuQiong ShiZhi-Xiang XuChunying LiColin R. GodingJun ZhouRutao CuiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuyang Chen Changpeng Han Xiao Miao Xin Li Chengqian Yin Junrong Zou Min Liu Shanshan Li Lukasz Stawski Bo Zhu Qiong Shi Zhi-Xiang Xu Chunying Li Colin R. Goding Jun Zhou Rutao Cui Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
description	Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit melanomagenesis in mice.
format	article
author	Shuyang Chen Changpeng Han Xiao Miao Xin Li Chengqian Yin Junrong Zou Min Liu Shanshan Li Lukasz Stawski Bo Zhu Qiong Shi Zhi-Xiang Xu Chunying Li Colin R. Goding Jun Zhou Rutao Cui
author_facet	Shuyang Chen Changpeng Han Xiao Miao Xin Li Chengqian Yin Junrong Zou Min Liu Shanshan Li Lukasz Stawski Bo Zhu Qiong Shi Zhi-Xiang Xu Chunying Li Colin R. Goding Jun Zhou Rutao Cui
author_sort	Shuyang Chen
title	Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
title_short	Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
title_full	Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
title_fullStr	Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
title_full_unstemmed	Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
title_sort	targeting mc1r depalmitoylation to prevent melanomagenesis in redheads
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d4cb91d255ff4330b7ffd8d024fa1867
work_keys_str_mv	AT shuyangchen targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT changpenghan targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT xiaomiao targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT xinli targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT chengqianyin targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT junrongzou targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT minliu targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT shanshanli targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT lukaszstawski targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT bozhu targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT qiongshi targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT zhixiangxu targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT chunyingli targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT colinrgoding targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT junzhou targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads AT rutaocui targetingmc1rdepalmitoylationtopreventmelanomagenesisinredheads
_version_	1718391100759080960

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

Ejemplares similares