Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration

Abstract Abdominal wall defect caused by open abdomen (OA) or abdominal trauma is a serious issue since it induces several clinical problems. Although a variety of prosthetic materials are commonly employed, complications occur including host soft tissue response, fistula formation and chronic patie...

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Autores principales:	Youming Deng, Jianan Ren, Guopu Chen, Guanwei Li, Xiuwen Wu, Gefei Wang, Guosheng Gu, Jieshou Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4cc6627be354173803dfc80bed03bf7
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spelling	oai:doaj.org-article:d4cc6627be354173803dfc80bed03bf72021-12-02T16:07:45ZInjectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration10.1038/s41598-017-02962-z2045-2322https://doaj.org/article/d4cc6627be354173803dfc80bed03bf72017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02962-zhttps://doaj.org/toc/2045-2322Abstract Abdominal wall defect caused by open abdomen (OA) or abdominal trauma is a serious issue since it induces several clinical problems. Although a variety of prosthetic materials are commonly employed, complications occur including host soft tissue response, fistula formation and chronic patient discomfort. Recently, abundant natural polymers have been used for injectable hydrogel synthesis in tissue regeneration. In this study, we produced the chitosan - hyaluronic acid (CS/HA) hydrogel and investigated its effects on abdominal tissue regeneration. The physical and biological properties of the hydrogel were demonstrated to be suitable for application in abdominal wounds. In a rat model simulating open abdomen and large abdominal wall defect, rapid cellular response, sufficient ECM deposition and marked neovascularization were found after the application of the hydrogel, compared to the control group and fibrin gel group. Further, the possible mechanism of these findings was studied. Cytokines involved in angiogenesis and cellular response were increased and the skew toward M2 macrophages credited with the functions of anti-inflammation and tissue repair was showed in CS/HA hydrogel group. These findings suggested that CS/HA hydrogel could prevent the complications and was promising for abdominal tissue regeneration.Youming DengJianan RenGuopu ChenGuanwei LiXiuwen WuGefei WangGuosheng GuJieshou LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Youming Deng Jianan Ren Guopu Chen Guanwei Li Xiuwen Wu Gefei Wang Guosheng Gu Jieshou Li Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration
description	Abstract Abdominal wall defect caused by open abdomen (OA) or abdominal trauma is a serious issue since it induces several clinical problems. Although a variety of prosthetic materials are commonly employed, complications occur including host soft tissue response, fistula formation and chronic patient discomfort. Recently, abundant natural polymers have been used for injectable hydrogel synthesis in tissue regeneration. In this study, we produced the chitosan - hyaluronic acid (CS/HA) hydrogel and investigated its effects on abdominal tissue regeneration. The physical and biological properties of the hydrogel were demonstrated to be suitable for application in abdominal wounds. In a rat model simulating open abdomen and large abdominal wall defect, rapid cellular response, sufficient ECM deposition and marked neovascularization were found after the application of the hydrogel, compared to the control group and fibrin gel group. Further, the possible mechanism of these findings was studied. Cytokines involved in angiogenesis and cellular response were increased and the skew toward M2 macrophages credited with the functions of anti-inflammation and tissue repair was showed in CS/HA hydrogel group. These findings suggested that CS/HA hydrogel could prevent the complications and was promising for abdominal tissue regeneration.
format	article
author	Youming Deng Jianan Ren Guopu Chen Guanwei Li Xiuwen Wu Gefei Wang Guosheng Gu Jieshou Li
author_facet	Youming Deng Jianan Ren Guopu Chen Guanwei Li Xiuwen Wu Gefei Wang Guosheng Gu Jieshou Li
author_sort	Youming Deng
title	Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration
title_short	Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration
title_full	Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration
title_fullStr	Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration
title_full_unstemmed	Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration
title_sort	injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d4cc6627be354173803dfc80bed03bf7
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Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration

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