The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats

Mansour Amraei,1,* Ayub Ghorbani,1,* Yaser Seifinejad,1 Seyedeh Fatemeh Mousavi,2 Mahmoud Mohamadpour,3 Ehsan Shirzadpour3 1Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran; 2Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran; 3D...

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Autores principales:	Amraei M, Ghorbani A, Seifinejad Y, Mousavi SF, Mohamadpour M, Shirzadpour E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Teucrium polium Inflammatory markers Lipid Profile Male Rat. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d4ce5da9c8204303b95e2814d097d9a7
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spelling	oai:doaj.org-article:d4ce5da9c8204303b95e2814d097d9a72021-12-02T03:07:57ZThe effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats1178-7031https://doaj.org/article/d4ce5da9c8204303b95e2814d097d9a72018-06-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-hydroalcoholic-extract-of-teucrium-polium-l-on-the-infla-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Mansour Amraei,1,* Ayub Ghorbani,1,* Yaser Seifinejad,1 Seyedeh Fatemeh Mousavi,2 Mahmoud Mohamadpour,3 Ehsan Shirzadpour3 1Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran; 2Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran; 3Department of Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran *These authors contributed equally to this work Background: Cardiovascular diseases are among the most common causes of mortality worldwide. Therefore, it is necessary to control the risk factors of these patients. Since the level of inflammatory markers and lipid profiles has increased in cardiovascular diseases and due to the increasing role of plants in the treatment of diseases, the current study aimed to investigate the effect of hydroalcoholic extract of Teucrium polium on inflammatory markers and lipid profile in hypercholesterolemic rats.Materials and methods: A total of 24 adult male Wistar rats were randomly divided into four groups of six each and treated with oral administration for 8 weeks. The control group received normal diet, the sham group received high-cholesterol diet and experimental groups 1 and 2 received high-cholesterol diet in the 8 weeks and doses of 85 and 170 mg/kg, respectively, of the T. polium hydroalcoholic extract (TPHAE) in the second 4 weeks. At the beginning and the end of the study, rats were examined for biochemical parameters. The mean level of variables for each group was presented as mean ± standard error of mean.Results: The results of this study showed that, after administration of TPHAE, there was a significant decrease in the mean of inflammatory markers in all groups compared to sham group (P<0.001). Also, administration of the extract significantly reduced the serum levels of triglyceride, cholesterol and LDL-cholesterol and significantly increased the serum HDL-cholesterol levels. In addition, the 170 mg/kg dose of TPHAE was the most effective in reducing serum levels of inflammatory and lipid markers.Conclusion: Treatment with TPHAE caused dose-dependent decrease in serum levels of inflammatory markers and lipid profile in hypercholesterolemic rats. Therefore, it can be applied as a natural product for the management of cardiovascular diseases. Keywords: Teucrium polium, inflammatory markers, lipid profile, male rat Amraei MGhorbani ASeifinejad YMousavi SFMohamadpour MShirzadpour EDove Medical PressarticleTeucrium poliumInflammatory markersLipid ProfileMale Rat.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 265-272 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Teucrium polium Inflammatory markers Lipid Profile Male Rat. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Teucrium polium Inflammatory markers Lipid Profile Male Rat. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Amraei M Ghorbani A Seifinejad Y Mousavi SF Mohamadpour M Shirzadpour E The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats
description	Mansour Amraei,1,* Ayub Ghorbani,1,* Yaser Seifinejad,1 Seyedeh Fatemeh Mousavi,2 Mahmoud Mohamadpour,3 Ehsan Shirzadpour3 1Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran; 2Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran; 3Department of Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran *These authors contributed equally to this work Background: Cardiovascular diseases are among the most common causes of mortality worldwide. Therefore, it is necessary to control the risk factors of these patients. Since the level of inflammatory markers and lipid profiles has increased in cardiovascular diseases and due to the increasing role of plants in the treatment of diseases, the current study aimed to investigate the effect of hydroalcoholic extract of Teucrium polium on inflammatory markers and lipid profile in hypercholesterolemic rats.Materials and methods: A total of 24 adult male Wistar rats were randomly divided into four groups of six each and treated with oral administration for 8 weeks. The control group received normal diet, the sham group received high-cholesterol diet and experimental groups 1 and 2 received high-cholesterol diet in the 8 weeks and doses of 85 and 170 mg/kg, respectively, of the T. polium hydroalcoholic extract (TPHAE) in the second 4 weeks. At the beginning and the end of the study, rats were examined for biochemical parameters. The mean level of variables for each group was presented as mean ± standard error of mean.Results: The results of this study showed that, after administration of TPHAE, there was a significant decrease in the mean of inflammatory markers in all groups compared to sham group (P<0.001). Also, administration of the extract significantly reduced the serum levels of triglyceride, cholesterol and LDL-cholesterol and significantly increased the serum HDL-cholesterol levels. In addition, the 170 mg/kg dose of TPHAE was the most effective in reducing serum levels of inflammatory and lipid markers.Conclusion: Treatment with TPHAE caused dose-dependent decrease in serum levels of inflammatory markers and lipid profile in hypercholesterolemic rats. Therefore, it can be applied as a natural product for the management of cardiovascular diseases. Keywords: Teucrium polium, inflammatory markers, lipid profile, male rat
format	article
author	Amraei M Ghorbani A Seifinejad Y Mousavi SF Mohamadpour M Shirzadpour E
author_facet	Amraei M Ghorbani A Seifinejad Y Mousavi SF Mohamadpour M Shirzadpour E
author_sort	Amraei M
title	The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats
title_short	The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats
title_full	The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats
title_fullStr	The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats
title_full_unstemmed	The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats
title_sort	effect of hydroalcoholic extract of teucrium polium l. on the inflammatory markers and lipid profile in hypercholesterolemic rats
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d4ce5da9c8204303b95e2814d097d9a7
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The effect of hydroalcoholic extract of Teucrium polium L. on the inflammatory markers and lipid profile in hypercholesterolemic rats

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