CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer

Abstract To stratify the heterogeneity of prostate cancer (PCa) with seminal vesicle invasion (SVI) immunologically after radical prostatectomy focusing on the tumor microenvironment. We retrospectively reviewed the clinicopathological data of 71 PCa patients with SVI, which is known as a factor of...

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Autores principales:	Yoshinori Yanai, Takeo Kosaka, Shuji Mikami, Hiroshi Hongo, Yota Yasumizu, Toshikazu Takeda, Kazuhiro Matsumoto, Jun Miyauchi, Shigehisa Kitano, Mototsugu Oya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4d29165ddca4fb0be5007d5086791f2
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spelling	oai:doaj.org-article:d4d29165ddca4fb0be5007d5086791f22021-11-21T12:16:38ZCD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer10.1038/s41598-021-01900-42045-2322https://doaj.org/article/d4d29165ddca4fb0be5007d5086791f22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01900-4https://doaj.org/toc/2045-2322Abstract To stratify the heterogeneity of prostate cancer (PCa) with seminal vesicle invasion (SVI) immunologically after radical prostatectomy focusing on the tumor microenvironment. We retrospectively reviewed the clinicopathological data of 71 PCa patients with SVI, which is known as a factor of very high-risk PCa. Preoperative clinical variables and postoperative pathological variables were evaluated as predictors of biochemical recurrence (BCR) with a multivariate logistic regression. Immune cell infiltration including the CD8-positive cell (CD8+ cell) and CD204-positive M2-like macrophage (CD204+ cell) was investigated by immunohistochemistry. The cumulative incidence and risk of BCR were assessed with a Kaplan–Meier analysis and competing risks regression. A higher CD8+ cell count in the SVI area significantly indicated a favorable prognosis for cancers with SVI (p = 0.004). A lower CD204+ cell count in the SVI area also significantly indicated a favorable prognosis for cancers with SVI (p = 0.004). Furthermore, the combination of the CD8+ and CD204+ cell infiltration ratio of the SVI area to the main tumor area was a significant factor for BCR in the patients with the PCa with SVI (p = 0.001). In PCa patients with SVI, the combination of CD8+ and CD204+ cell infiltration is useful to predict the prognosis.Yoshinori YanaiTakeo KosakaShuji MikamiHiroshi HongoYota YasumizuToshikazu TakedaKazuhiro MatsumotoJun MiyauchiShigehisa KitanoMototsugu OyaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshinori Yanai Takeo Kosaka Shuji Mikami Hiroshi Hongo Yota Yasumizu Toshikazu Takeda Kazuhiro Matsumoto Jun Miyauchi Shigehisa Kitano Mototsugu Oya CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer
description	Abstract To stratify the heterogeneity of prostate cancer (PCa) with seminal vesicle invasion (SVI) immunologically after radical prostatectomy focusing on the tumor microenvironment. We retrospectively reviewed the clinicopathological data of 71 PCa patients with SVI, which is known as a factor of very high-risk PCa. Preoperative clinical variables and postoperative pathological variables were evaluated as predictors of biochemical recurrence (BCR) with a multivariate logistic regression. Immune cell infiltration including the CD8-positive cell (CD8+ cell) and CD204-positive M2-like macrophage (CD204+ cell) was investigated by immunohistochemistry. The cumulative incidence and risk of BCR were assessed with a Kaplan–Meier analysis and competing risks regression. A higher CD8+ cell count in the SVI area significantly indicated a favorable prognosis for cancers with SVI (p = 0.004). A lower CD204+ cell count in the SVI area also significantly indicated a favorable prognosis for cancers with SVI (p = 0.004). Furthermore, the combination of the CD8+ and CD204+ cell infiltration ratio of the SVI area to the main tumor area was a significant factor for BCR in the patients with the PCa with SVI (p = 0.001). In PCa patients with SVI, the combination of CD8+ and CD204+ cell infiltration is useful to predict the prognosis.
format	article
author	Yoshinori Yanai Takeo Kosaka Shuji Mikami Hiroshi Hongo Yota Yasumizu Toshikazu Takeda Kazuhiro Matsumoto Jun Miyauchi Shigehisa Kitano Mototsugu Oya
author_facet	Yoshinori Yanai Takeo Kosaka Shuji Mikami Hiroshi Hongo Yota Yasumizu Toshikazu Takeda Kazuhiro Matsumoto Jun Miyauchi Shigehisa Kitano Mototsugu Oya
author_sort	Yoshinori Yanai
title	CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer
title_short	CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer
title_full	CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer
title_fullStr	CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer
title_full_unstemmed	CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer
title_sort	cd8-positive t cells and cd204-positive m2-like macrophages predict postoperative prognosis of very high-risk prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d4d29165ddca4fb0be5007d5086791f2
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CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer

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