Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder

Functional connectivity, quantified by phase synchrony, between brain regions is known to be aberrant in patients with autism spectrum disorder (ASD). Here, we evaluated the long-range temporal correlations of time-varying phase synchrony (TV-PS) of electrocortical oscillations in patients with ASD...

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Autores principales:	Huibin Jia, Fei Gao, Dongchuan Yu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	phase synchrony long-range temporal correlations detrended fluctuation analysis autism spectrum disorder default mode network mirror neuron system Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/d4d5507ac71946baaa8fd36973a38be0
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id	oai:doaj.org-article:d4d5507ac71946baaa8fd36973a38be0
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spelling	oai:doaj.org-article:d4d5507ac71946baaa8fd36973a38be02021-11-10T06:47:05ZAltered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder1664-064010.3389/fpsyt.2021.618573https://doaj.org/article/d4d5507ac71946baaa8fd36973a38be02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.618573/fullhttps://doaj.org/toc/1664-0640Functional connectivity, quantified by phase synchrony, between brain regions is known to be aberrant in patients with autism spectrum disorder (ASD). Here, we evaluated the long-range temporal correlations of time-varying phase synchrony (TV-PS) of electrocortical oscillations in patients with ASD as well as typically developing people using detrended fluctuation analysis (DFA) after validating the scale-invariance of the TV-PS time series. By comparing the DFA exponents between the two groups, we found that those of the TV-PS time series of high-gamma oscillations were significantly attenuated in patients with ASD. Furthermore, the regions involved in aberrant TV-PS time series were mainly within the social ability and cognition-related cortical networks. These results support the notion that abnormal social functions observed in patients with ASD may be caused by the highly volatile phase synchrony states of electrocortical oscillations.Huibin JiaHuibin JiaHuibin JiaHuibin JiaFei GaoDongchuan YuFrontiers Media S.A.articlephase synchronylong-range temporal correlationsdetrended fluctuation analysisautism spectrum disorderdefault mode networkmirror neuron systemPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phase synchrony long-range temporal correlations detrended fluctuation analysis autism spectrum disorder default mode network mirror neuron system Psychiatry RC435-571
spellingShingle	phase synchrony long-range temporal correlations detrended fluctuation analysis autism spectrum disorder default mode network mirror neuron system Psychiatry RC435-571 Huibin Jia Huibin Jia Huibin Jia Huibin Jia Fei Gao Dongchuan Yu Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder
description	Functional connectivity, quantified by phase synchrony, between brain regions is known to be aberrant in patients with autism spectrum disorder (ASD). Here, we evaluated the long-range temporal correlations of time-varying phase synchrony (TV-PS) of electrocortical oscillations in patients with ASD as well as typically developing people using detrended fluctuation analysis (DFA) after validating the scale-invariance of the TV-PS time series. By comparing the DFA exponents between the two groups, we found that those of the TV-PS time series of high-gamma oscillations were significantly attenuated in patients with ASD. Furthermore, the regions involved in aberrant TV-PS time series were mainly within the social ability and cognition-related cortical networks. These results support the notion that abnormal social functions observed in patients with ASD may be caused by the highly volatile phase synchrony states of electrocortical oscillations.
format	article
author	Huibin Jia Huibin Jia Huibin Jia Huibin Jia Fei Gao Dongchuan Yu
author_facet	Huibin Jia Huibin Jia Huibin Jia Huibin Jia Fei Gao Dongchuan Yu
author_sort	Huibin Jia
title	Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder
title_short	Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder
title_full	Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder
title_fullStr	Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder
title_full_unstemmed	Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder
title_sort	altered temporal structure of neural phase synchrony in patients with autism spectrum disorder
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d4d5507ac71946baaa8fd36973a38be0
work_keys_str_mv	AT huibinjia alteredtemporalstructureofneuralphasesynchronyinpatientswithautismspectrumdisorder AT huibinjia alteredtemporalstructureofneuralphasesynchronyinpatientswithautismspectrumdisorder AT huibinjia alteredtemporalstructureofneuralphasesynchronyinpatientswithautismspectrumdisorder AT huibinjia alteredtemporalstructureofneuralphasesynchronyinpatientswithautismspectrumdisorder AT feigao alteredtemporalstructureofneuralphasesynchronyinpatientswithautismspectrumdisorder AT dongchuanyu alteredtemporalstructureofneuralphasesynchronyinpatientswithautismspectrumdisorder
_version_	1718440514634645504

Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder

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