Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation

Aim. To evaluate effect of different factors on pregnancy course in patients with type 1 diabetes mellitus developing in the prepubertal period. Materials and methods. The study based at Endocrinological Research Centre included 77 women with prepubertal diabetes 18 of whom developedpregnancy that...

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Autores principales:	Lyubov' Leonidovna Bolotskaya, Natalya Vladimirovna Efremova, Yury Ivanovich Suntsov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	diabetes mellitus pregnancy insulin therapy microvascular complications Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/d4da899274374c6e804f7c88c3285d2a
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spelling	oai:doaj.org-article:d4da899274374c6e804f7c88c3285d2a2021-11-14T09:00:14ZSpecific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation2072-03512072-037810.14341/2072-0351-5700https://doaj.org/article/d4da899274374c6e804f7c88c3285d2a2009-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5700https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate effect of different factors on pregnancy course in patients with type 1 diabetes mellitus developing in the prepubertal period. Materials and methods. The study based at Endocrinological Research Centre included 77 women with prepubertal diabetes 18 of whom developedpregnancy that ended in delivery. Results. As per 2009, the age of the patients is 26,6?4,6 years. They became pregnant at 23,2?3,3 years and had had diabetes since the age of9,6?4,8 years. Their HbA1c level before and after pregnancy was 8,6?1,4 and 6,8?1,6% respectively, the difference being insignificant (p=0,3).Significant difference was documented between these HbA1c levels and that during pregnancy (p=0,0004 and 0.003 respectively). Nine (56,2%) patientsused ultrashort-acting insulin analogs and the remaining 7 (43,7%) recombinant human insulins. The mean insulin dose was 43,7?11 U/din the 1st trimester, 51,8?13,7 U/d in the 2bd trimester, and 45,3?10,8 U/d after delivery. 16 (88%) of the patients reported frequent hypoglycemia,five (27,8%) of them had episodes of severe daytime and nocturnal hypoglycemia. 11 (61%) developed microvascular diabetic complications beforepregnancy, with 9 (50%) having DR and 4 (22,2%) DN (microalbuminuria). The delivery occurred on weeks 36-37 in 7 (38,9%) women. Naturaland cesarean section deliveries took place in one and 17 (94,4%) patients respectively. Conclusion. Long-term follow-up of patients wit DM1 in accordance with algorithms of specialized medical aid to DM1 patients in Russia at a multidisciplinaryendocrinological centre decreases the risk of pregnancy and delivery complications and that of microvascular diabetic complicationsLyubov' Leonidovna BolotskayaNatalya Vladimirovna EfremovaYury Ivanovich SuntsovEndocrinology Research Centrearticlediabetes mellituspregnancyinsulin therapymicrovascular complicationsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 4, Pp 28-31 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus pregnancy insulin therapy microvascular complications Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus pregnancy insulin therapy microvascular complications Nutritional diseases. Deficiency diseases RC620-627 Lyubov' Leonidovna Bolotskaya Natalya Vladimirovna Efremova Yury Ivanovich Suntsov Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation
description	Aim. To evaluate effect of different factors on pregnancy course in patients with type 1 diabetes mellitus developing in the prepubertal period. Materials and methods. The study based at Endocrinological Research Centre included 77 women with prepubertal diabetes 18 of whom developedpregnancy that ended in delivery. Results. As per 2009, the age of the patients is 26,6?4,6 years. They became pregnant at 23,2?3,3 years and had had diabetes since the age of9,6?4,8 years. Their HbA1c level before and after pregnancy was 8,6?1,4 and 6,8?1,6% respectively, the difference being insignificant (p=0,3).Significant difference was documented between these HbA1c levels and that during pregnancy (p=0,0004 and 0.003 respectively). Nine (56,2%) patientsused ultrashort-acting insulin analogs and the remaining 7 (43,7%) recombinant human insulins. The mean insulin dose was 43,7?11 U/din the 1st trimester, 51,8?13,7 U/d in the 2bd trimester, and 45,3?10,8 U/d after delivery. 16 (88%) of the patients reported frequent hypoglycemia,five (27,8%) of them had episodes of severe daytime and nocturnal hypoglycemia. 11 (61%) developed microvascular diabetic complications beforepregnancy, with 9 (50%) having DR and 4 (22,2%) DN (microalbuminuria). The delivery occurred on weeks 36-37 in 7 (38,9%) women. Naturaland cesarean section deliveries took place in one and 17 (94,4%) patients respectively. Conclusion. Long-term follow-up of patients wit DM1 in accordance with algorithms of specialized medical aid to DM1 patients in Russia at a multidisciplinaryendocrinological centre decreases the risk of pregnancy and delivery complications and that of microvascular diabetic complications
format	article
author	Lyubov' Leonidovna Bolotskaya Natalya Vladimirovna Efremova Yury Ivanovich Suntsov
author_facet	Lyubov' Leonidovna Bolotskaya Natalya Vladimirovna Efremova Yury Ivanovich Suntsov
author_sort	Lyubov' Leonidovna Bolotskaya
title	Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation
title_short	Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation
title_full	Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation
title_fullStr	Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation
title_full_unstemmed	Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation
title_sort	specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. results of a 15-year long clinical observation
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/d4da899274374c6e804f7c88c3285d2a
work_keys_str_mv	AT lyubovleonidovnabolotskaya specificfeaturesofpregnancyinpatientswithtype1diabetesintheprepubertalperiodresultsofa15yearlongclinicalobservation AT natalyavladimirovnaefremova specificfeaturesofpregnancyinpatientswithtype1diabetesintheprepubertalperiodresultsofa15yearlongclinicalobservation AT yuryivanovichsuntsov specificfeaturesofpregnancyinpatientswithtype1diabetesintheprepubertalperiodresultsofa15yearlongclinicalobservation
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Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation

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