Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25

Cancer cell-derived exosomes regulate tumor growth and progression. However, the effects of exosomes and its contents on head and neck squamous cell carcinoma (HNSCC) and its underlying mechanisms remain unclear. Here, we found HNSCC displayed a dysregulation of exosomes biogenesis. miR-185-3p was o...

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Autores principales:	Xueping Wang, Xiaoyuan Zhu, Yulin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	head and neck squamous cell carcinoma exosome miR-185-3p RAB25 tumor growth Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d4db6a0c26f044419283560f93007039
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id	oai:doaj.org-article:d4db6a0c26f044419283560f93007039
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spelling	oai:doaj.org-article:d4db6a0c26f044419283560f930070392021-11-15T04:29:20ZTargeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB252234-943X10.3389/fonc.2021.721416https://doaj.org/article/d4db6a0c26f044419283560f930070392021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.721416/fullhttps://doaj.org/toc/2234-943XCancer cell-derived exosomes regulate tumor growth and progression. However, the effects of exosomes and its contents on head and neck squamous cell carcinoma (HNSCC) and its underlying mechanisms remain unclear. Here, we found HNSCC displayed a dysregulation of exosomes biogenesis. miR-185-3p was one of the most upregulated exosome-derived miRNAs in HNSCC. Functional assay showed that RAB25 is a direct downstream target of miR-185-3p. miR-185-3p/RAB25 signaling controlled tumor progression and correlated with disease prognosis. Targeting miR-185-3p/RAB25 significantly inhibited tumor growth and promoted drug response to chemotherapy. To conclude, the findings demonstrate exosomal miR-185-3p promotes tumor growth by mediating RAB25 that could be effectively targeted for HNSCC treatment.Xueping WangXiaoyuan ZhuYulin ZhaoFrontiers Media S.A.articlehead and neck squamous cell carcinomaexosomemiR-185-3pRAB25tumor growthNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck squamous cell carcinoma exosome miR-185-3p RAB25 tumor growth Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	head and neck squamous cell carcinoma exosome miR-185-3p RAB25 tumor growth Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xueping Wang Xiaoyuan Zhu Yulin Zhao Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25
description	Cancer cell-derived exosomes regulate tumor growth and progression. However, the effects of exosomes and its contents on head and neck squamous cell carcinoma (HNSCC) and its underlying mechanisms remain unclear. Here, we found HNSCC displayed a dysregulation of exosomes biogenesis. miR-185-3p was one of the most upregulated exosome-derived miRNAs in HNSCC. Functional assay showed that RAB25 is a direct downstream target of miR-185-3p. miR-185-3p/RAB25 signaling controlled tumor progression and correlated with disease prognosis. Targeting miR-185-3p/RAB25 significantly inhibited tumor growth and promoted drug response to chemotherapy. To conclude, the findings demonstrate exosomal miR-185-3p promotes tumor growth by mediating RAB25 that could be effectively targeted for HNSCC treatment.
format	article
author	Xueping Wang Xiaoyuan Zhu Yulin Zhao
author_facet	Xueping Wang Xiaoyuan Zhu Yulin Zhao
author_sort	Xueping Wang
title	Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25
title_short	Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25
title_full	Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25
title_fullStr	Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25
title_full_unstemmed	Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25
title_sort	targeting mir-185-3p inhibits head and neck squamous cell carcinoma by modulating rab25
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d4db6a0c26f044419283560f93007039
work_keys_str_mv	AT xuepingwang targetingmir1853pinhibitsheadandnecksquamouscellcarcinomabymodulatingrab25 AT xiaoyuanzhu targetingmir1853pinhibitsheadandnecksquamouscellcarcinomabymodulatingrab25 AT yulinzhao targetingmir1853pinhibitsheadandnecksquamouscellcarcinomabymodulatingrab25
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Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25

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