Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.

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Autores principales:	Srinath C. Sampath, Srihari C. Sampath, Andrew T. V. Ho, Stéphane Y. Corbel, Joshua D. Millstone, John Lamb, John Walker, Bernd Kinzel, Christian Schmedt, Helen M. Blau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4e2ae2b17c54b96800222a5fe7090a1
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spelling	oai:doaj.org-article:d4e2ae2b17c54b96800222a5fe7090a12021-12-02T16:49:18ZInduction of muscle stem cell quiescence by the secreted niche factor Oncostatin M10.1038/s41467-018-03876-82041-1723https://doaj.org/article/d4e2ae2b17c54b96800222a5fe7090a12018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03876-8https://doaj.org/toc/2041-1723The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.Srinath C. SampathSrihari C. SampathAndrew T. V. HoStéphane Y. CorbelJoshua D. MillstoneJohn LambJohn WalkerBernd KinzelChristian SchmedtHelen M. BlauNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Srinath C. Sampath Srihari C. Sampath Andrew T. V. Ho Stéphane Y. Corbel Joshua D. Millstone John Lamb John Walker Bernd Kinzel Christian Schmedt Helen M. Blau Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
description	The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.
format	article
author	Srinath C. Sampath Srihari C. Sampath Andrew T. V. Ho Stéphane Y. Corbel Joshua D. Millstone John Lamb John Walker Bernd Kinzel Christian Schmedt Helen M. Blau
author_facet	Srinath C. Sampath Srihari C. Sampath Andrew T. V. Ho Stéphane Y. Corbel Joshua D. Millstone John Lamb John Walker Bernd Kinzel Christian Schmedt Helen M. Blau
author_sort	Srinath C. Sampath
title	Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
title_short	Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
title_full	Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
title_fullStr	Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
title_full_unstemmed	Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
title_sort	induction of muscle stem cell quiescence by the secreted niche factor oncostatin m
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d4e2ae2b17c54b96800222a5fe7090a1
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Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

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