WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS

This article considers the wound-healing effect of a hydrogel based on polyhexamethyleneguanidine hydrochloride under conditions of thermal shock modeling. The presence of gelling properties in combination with the high biocidal activity of polyguanidins opens the prospect of obtaining an effective...

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Autores principales:	S. N. Lebedeva, O. S. Ochirov, S. A. Stelmakh, M. N. Grigoryeva, S. D. Zhamsaranova, D. M. Mognonov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	polyhexamethieneguanidine hydrochloride hydrogel burns wound-healing effect Science Q
Acceso en línea:	https://doaj.org/article/d4e46e199fb948cfae12f5ce70a187d4
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spelling	oai:doaj.org-article:d4e46e199fb948cfae12f5ce70a187d42021-11-23T06:14:38ZWOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS2541-94202587-959610.12737/article_59fad51d481658.42549272https://doaj.org/article/d4e46e199fb948cfae12f5ce70a187d42017-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/420https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596This article considers the wound-healing effect of a hydrogel based on polyhexamethyleneguanidine hydrochloride under conditions of thermal shock modeling. The presence of gelling properties in combination with the high biocidal activity of polyguanidins opens the prospect of obtaining an effective single-component external agent, which is very important for antimicrobial chemotherapy of wounds and burns, as in their treatment there is a high probability of infecting the wound with microorganisms causing various infectious diseases. Previously, we developed a method for the preparation of a hydrogel based on polyhexamethyleneguanidine hydrochloride, which involves the cross-linking of the amino-end groups of the branched polymer with formaldehyde, resulting in a cross-linked polymer, which is a lump-like mass. The mechanical treatment of the hydrogel makes it possible to give the material an ointment form that is convenient for application to the skin. An experiment on the evaluation of the wound healing action of hydrogel was carried out under the conditions of modeling a thermal burn. The comparative preparation was multicomponent gel "Levomekol", in which polyethylene oxide was used as the basis. It was established that the hydrogel activates the growth of antioxidants and leukocytes in the blood of animals in dynamics on the 10th, 17th and 24th day of the experiment, amounting to 56.4 %, 33.8 % and 20.9 %, and of leukocytes - 27.7 %, 19.6 %; 6,2 % in relation to the norm. The method of contrast radiography of penetrating wounds showed that the daily reduction in the wound area is most pronounced in the hydrogel group, which indicates a pronounced reparative effect.S. N. LebedevaO. S. OchirovS. A. StelmakhM. N. GrigoryevaS. D. ZhamsaranovaD. M. MognonovScientific Сentre for Family Health and Human Reproduction Problemsarticlepolyhexamethieneguanidine hydrochloridehydrogelburnswound-healing effectScienceQRUActa Biomedica Scientifica, Vol 2, Iss 4, Pp 93-96 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	polyhexamethieneguanidine hydrochloride hydrogel burns wound-healing effect Science Q
spellingShingle	polyhexamethieneguanidine hydrochloride hydrogel burns wound-healing effect Science Q S. N. Lebedeva O. S. Ochirov S. A. Stelmakh M. N. Grigoryeva S. D. Zhamsaranova D. M. Mognonov WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS
description	This article considers the wound-healing effect of a hydrogel based on polyhexamethyleneguanidine hydrochloride under conditions of thermal shock modeling. The presence of gelling properties in combination with the high biocidal activity of polyguanidins opens the prospect of obtaining an effective single-component external agent, which is very important for antimicrobial chemotherapy of wounds and burns, as in their treatment there is a high probability of infecting the wound with microorganisms causing various infectious diseases. Previously, we developed a method for the preparation of a hydrogel based on polyhexamethyleneguanidine hydrochloride, which involves the cross-linking of the amino-end groups of the branched polymer with formaldehyde, resulting in a cross-linked polymer, which is a lump-like mass. The mechanical treatment of the hydrogel makes it possible to give the material an ointment form that is convenient for application to the skin. An experiment on the evaluation of the wound healing action of hydrogel was carried out under the conditions of modeling a thermal burn. The comparative preparation was multicomponent gel "Levomekol", in which polyethylene oxide was used as the basis. It was established that the hydrogel activates the growth of antioxidants and leukocytes in the blood of animals in dynamics on the 10th, 17th and 24th day of the experiment, amounting to 56.4 %, 33.8 % and 20.9 %, and of leukocytes - 27.7 %, 19.6 %; 6,2 % in relation to the norm. The method of contrast radiography of penetrating wounds showed that the daily reduction in the wound area is most pronounced in the hydrogel group, which indicates a pronounced reparative effect.
format	article
author	S. N. Lebedeva O. S. Ochirov S. A. Stelmakh M. N. Grigoryeva S. D. Zhamsaranova D. M. Mognonov
author_facet	S. N. Lebedeva O. S. Ochirov S. A. Stelmakh M. N. Grigoryeva S. D. Zhamsaranova D. M. Mognonov
author_sort	S. N. Lebedeva
title	WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS
title_short	WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS
title_full	WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS
title_fullStr	WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS
title_full_unstemmed	WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS
title_sort	wound healing effect of polyhexamethylene guanidine hydrochloride hydrogelat burns
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/d4e46e199fb948cfae12f5ce70a187d4
work_keys_str_mv	AT snlebedeva woundhealingeffectofpolyhexamethyleneguanidinehydrochloridehydrogelatburns AT osochirov woundhealingeffectofpolyhexamethyleneguanidinehydrochloridehydrogelatburns AT sastelmakh woundhealingeffectofpolyhexamethyleneguanidinehydrochloridehydrogelatburns AT mngrigoryeva woundhealingeffectofpolyhexamethyleneguanidinehydrochloridehydrogelatburns AT sdzhamsaranova woundhealingeffectofpolyhexamethyleneguanidinehydrochloridehydrogelatburns AT dmmognonov woundhealingeffectofpolyhexamethyleneguanidinehydrochloridehydrogelatburns
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WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS

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