ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)

Oxidative stress plays an important role in the pathogenesis a most of diseases. Important components of protecting cells from oxidative stress are antioxidant enzymes, whose activity is genetically determined, due to the presence in the structure of the alleles of genes. Antioxidant enzymes are cha...

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Autores principales:	L. I. Kolesnikova, T. A. Bairova, O. A. Pervushina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	polymorphism antioksidanteoy system superoxide dismutase paraoxonase catalase Science Q
Acceso en línea:	https://doaj.org/article/d4e6b1f5e4cd49c88d076f84df401205
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spelling	oai:doaj.org-article:d4e6b1f5e4cd49c88d076f84df4012052021-11-23T06:14:28ZETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)2541-94202587-9596https://doaj.org/article/d4e6b1f5e4cd49c88d076f84df4012052013-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1624https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Oxidative stress plays an important role in the pathogenesis a most of diseases. Important components of protecting cells from oxidative stress are antioxidant enzymes, whose activity is genetically determined, due to the presence in the structure of the alleles of genes. Antioxidant enzymes are characterized by population and individual differences in enzyme activity. The study of genetic variation in the population of the world and the history of the formation of its gene pool is one of the promising areas of modern population genetics. Genetic variability of antioxidant enzymes in the body has recently become the most attractive destination in the pathogenesis of many diseases. Due to the involvement of enzymes in the pathogenesis of antioxidant enzymes social diseases is an important implementation. Comprehensive study of the genetic polymorphisms of genes contributes to the formation of human disease susceptibility. The antioxidant system is of the person a system that blocks the formation of free radicals, highly active oxygen. Under normal physiological conditions, a small amount of oxygen is constantly converted to superoxide anions, hydrogen peroxide and hydroxyl radicals. Excessive production of these radicals is a factor of injury; compensatory mechanism is the antioxidant system. The main component of this system is a network of antioxidant enzymes (AOP): superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and paraoxonase (PON). In this case, the activity of enzymes evolutionarily and genetically programmed to optimize the balance of oxidative processes and the activity of antioxidant defense systems. The purpose of the review is to summarize and discuss the current data on genetic polymorphisms of antioxidant enzymes in certain pathologies, the development of which plays the role of oxidative stress.L. I. KolesnikovaT. A. BairovaO. A. PervushinaScientific Сentre for Family Health and Human Reproduction Problemsarticlepolymorphismantioksidanteoy systemsuperoxide dismutaseparaoxonasecatalaseScienceQRUActa Biomedica Scientifica, Vol 0, Iss 4, Pp 166-171 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	polymorphism antioksidanteoy system superoxide dismutase paraoxonase catalase Science Q
spellingShingle	polymorphism antioksidanteoy system superoxide dismutase paraoxonase catalase Science Q L. I. Kolesnikova T. A. Bairova O. A. Pervushina ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)
description	Oxidative stress plays an important role in the pathogenesis a most of diseases. Important components of protecting cells from oxidative stress are antioxidant enzymes, whose activity is genetically determined, due to the presence in the structure of the alleles of genes. Antioxidant enzymes are characterized by population and individual differences in enzyme activity. The study of genetic variation in the population of the world and the history of the formation of its gene pool is one of the promising areas of modern population genetics. Genetic variability of antioxidant enzymes in the body has recently become the most attractive destination in the pathogenesis of many diseases. Due to the involvement of enzymes in the pathogenesis of antioxidant enzymes social diseases is an important implementation. Comprehensive study of the genetic polymorphisms of genes contributes to the formation of human disease susceptibility. The antioxidant system is of the person a system that blocks the formation of free radicals, highly active oxygen. Under normal physiological conditions, a small amount of oxygen is constantly converted to superoxide anions, hydrogen peroxide and hydroxyl radicals. Excessive production of these radicals is a factor of injury; compensatory mechanism is the antioxidant system. The main component of this system is a network of antioxidant enzymes (AOP): superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and paraoxonase (PON). In this case, the activity of enzymes evolutionarily and genetically programmed to optimize the balance of oxidative processes and the activity of antioxidant defense systems. The purpose of the review is to summarize and discuss the current data on genetic polymorphisms of antioxidant enzymes in certain pathologies, the development of which plays the role of oxidative stress.
format	article
author	L. I. Kolesnikova T. A. Bairova O. A. Pervushina
author_facet	L. I. Kolesnikova T. A. Bairova O. A. Pervushina
author_sort	L. I. Kolesnikova
title	ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)
title_short	ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)
title_full	ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)
title_fullStr	ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)
title_full_unstemmed	ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)
title_sort	ethno-genetic markers of antioxidant system (literature review)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/d4e6b1f5e4cd49c88d076f84df401205
work_keys_str_mv	AT likolesnikova ethnogeneticmarkersofantioxidantsystemliteraturereview AT tabairova ethnogeneticmarkersofantioxidantsystemliteraturereview AT oapervushina ethnogeneticmarkersofantioxidantsystemliteraturereview
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ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)

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