Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight

Being born preterm (PT, <37 weeks gestation) or at very low birth weight (VLBW, <1500 g) is associated with increased rates of cardiopulmonary disorders in childhood. As survivors age, late cardiac effects, including right ventricular (RV) remodelling and occult pulmonary hypertension are emer...

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Autores principales:	Charlotte Greer, Sarah L. Harris, Richard Troughton, Philip D. Adamson, John Horwood, Chris Frampton, Brian A. Darlow
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular risk low birth weight preterm birth Medicine R
Acceso en línea:	https://doaj.org/article/d4e91f086a994db2895b6a741fcf9a1f
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spelling	oai:doaj.org-article:d4e91f086a994db2895b6a741fcf9a1f2021-11-11T17:31:35ZRight Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight10.3390/jcm102148642077-0383https://doaj.org/article/d4e91f086a994db2895b6a741fcf9a1f2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4864https://doaj.org/toc/2077-0383Being born preterm (PT, <37 weeks gestation) or at very low birth weight (VLBW, <1500 g) is associated with increased rates of cardiopulmonary disorders in childhood. As survivors age, late cardiac effects, including right ventricular (RV) remodelling and occult pulmonary hypertension are emerging. In this population-based study, we aimed to investigate right heart structure and function in young adults born PT at VLBW compared to normal-weight term-born controls. The New Zealand VLBW Study has followed all infants born in 1986 with birth weight <1500 g. All were born preterm from 24 to 37 weeks. A total of 229 (71% of survivors) had echocardiograms aged 26–30 years which were compared to age-matched, term-born, normal-weight controls (<i>n</i> = 100). Young adults born preterm at very low birth weight exhibited smaller RV dimensions compared to term-born peers. Standard echocardiographic measures of RV function did not differ, but mildly reduced function was detected by RV longitudinal strain. This difference was related to birth weight and gestational age but not lung function or left ventricular function. Echocardiographic strain imaging may be an important tool to detect differences in RV function preterm and VLBW.Charlotte GreerSarah L. HarrisRichard TroughtonPhilip D. AdamsonJohn HorwoodChris FramptonBrian A. DarlowMDPI AGarticlecardiovascular risklow birth weightpreterm birthMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4864, p 4864 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular risk low birth weight preterm birth Medicine R
spellingShingle	cardiovascular risk low birth weight preterm birth Medicine R Charlotte Greer Sarah L. Harris Richard Troughton Philip D. Adamson John Horwood Chris Frampton Brian A. Darlow Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight
description	Being born preterm (PT, <37 weeks gestation) or at very low birth weight (VLBW, <1500 g) is associated with increased rates of cardiopulmonary disorders in childhood. As survivors age, late cardiac effects, including right ventricular (RV) remodelling and occult pulmonary hypertension are emerging. In this population-based study, we aimed to investigate right heart structure and function in young adults born PT at VLBW compared to normal-weight term-born controls. The New Zealand VLBW Study has followed all infants born in 1986 with birth weight <1500 g. All were born preterm from 24 to 37 weeks. A total of 229 (71% of survivors) had echocardiograms aged 26–30 years which were compared to age-matched, term-born, normal-weight controls (<i>n</i> = 100). Young adults born preterm at very low birth weight exhibited smaller RV dimensions compared to term-born peers. Standard echocardiographic measures of RV function did not differ, but mildly reduced function was detected by RV longitudinal strain. This difference was related to birth weight and gestational age but not lung function or left ventricular function. Echocardiographic strain imaging may be an important tool to detect differences in RV function preterm and VLBW.
format	article
author	Charlotte Greer Sarah L. Harris Richard Troughton Philip D. Adamson John Horwood Chris Frampton Brian A. Darlow
author_facet	Charlotte Greer Sarah L. Harris Richard Troughton Philip D. Adamson John Horwood Chris Frampton Brian A. Darlow
author_sort	Charlotte Greer
title	Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight
title_short	Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight
title_full	Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight
title_fullStr	Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight
title_full_unstemmed	Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight
title_sort	right ventricular structure and function in young adults born preterm at very low birth weight
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d4e91f086a994db2895b6a741fcf9a1f
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Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight

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