Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates

Introduction: Intestinal fatty acid-binding protein (I-FABP) is located in the apex of mature enterocytes and released into circulation; once the injury of enterocyte happens, its circulating levels are considered an early and sensitive marker of intestinal ischemia as in necrotizing enterocolitis (...

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Autores principales:	Amin I E. Shaaban, Osama A E. Alfqy, Howayda M K. Shaaban, Yahya H A. Maqsoud, Effat H Assar
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	intestinal fatty acid-binding protein necrotizing enterocolitis premature preterm urinary intestinal-fatty acid-binding protein Pediatrics RJ1-570 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/d4e937e3197b4171ba8459bc8e78b317
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spelling	oai:doaj.org-article:d4e937e3197b4171ba8459bc8e78b3172021-11-19T10:42:05ZPotential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates0971-92611998-389110.4103/jiaps.JIAPS_218_20https://doaj.org/article/d4e937e3197b4171ba8459bc8e78b3172021-01-01T00:00:00Zhttp://www.jiaps.com/article.asp?issn=0971-9261;year=2021;volume=26;issue=6;spage=393;epage=400;aulast=E.https://doaj.org/toc/0971-9261https://doaj.org/toc/1998-3891Introduction: Intestinal fatty acid-binding protein (I-FABP) is located in the apex of mature enterocytes and released into circulation; once the injury of enterocyte happens, its circulating levels are considered an early and sensitive marker of intestinal ischemia as in necrotizing enterocolitis (NEC); because of its small molecular weight, it can be detected in urine. Aims: The aim was to study the usefulness of both serum and urine I-FABP in early diagnosis of NEC and to correlate the serum and urinary levels. Settings and Design: This study was case–control design. Methods: Simultaneous serum and urine samples obtained at the onset of symptoms, in 40 preterms with suspected NEC, with gestational age ± 27.70 weeks and birth weight ± 1.11 kg, i.e., 20 preterms diagnosed at Stage I, 12 preterms at Stage II, and 8 preterms at Stage III, were compared with age- and weight-matched preterms with no NEC. Statistical Analysis: The collected data were tabulated, coded, and then analyzed using the computer program Statistical Package for the Social Science (SPSS version 22). Results: Serum levels of I-FABP in NEC cases were significantly higher than the control group, with a mean of 6005.77 ± 6384.77 and 1480.79 ± 1276.48 pg/ml, respectively (P < 0.001). Urine levels of I-FABP in NEC cases were significantly higher than the control group, with a mean of 5009.22 ± 3941.64 and 2677.62 ± 2257.29 pg/ml, respectively (P = 0.04). Both serum and urine I-FABP levels not only in Stage II are significantly higher than Stage I but also in Stage III are significantly higher than Stage I and II (P < 0.001, P = 0.03, respectively), which showed significant positive correlation with stages of NEC (r = 0.618; P < 0.001; r = 0.306; P = 0.049, respectively). Both serum and urine I-FABP levels had a highly significant positive correlation with each other (r = 0.406 P < 0.0001). Receiving operating characteristic curve showed an area under the curve of 0.92 and 0.81 for serum and urine I-FABP, respectively. Conclusions: Whether serum or urinary I-FABP is valuable in the diagnosis and prediction of NEC and strongly correlated with the disease severity and with each other.Amin I E. ShaabanOsama A E. AlfqyHowayda M K. ShaabanYahya H A. MaqsoudEffat H AssarWolters Kluwer Medknow Publicationsarticleintestinal fatty acid-binding proteinnecrotizing enterocolitisprematurepretermurinary intestinal-fatty acid-binding proteinPediatricsRJ1-570SurgeryRD1-811ENJournal of Indian Association of Pediatric Surgeons, Vol 26, Iss 6, Pp 393-400 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intestinal fatty acid-binding protein necrotizing enterocolitis premature preterm urinary intestinal-fatty acid-binding protein Pediatrics RJ1-570 Surgery RD1-811
spellingShingle	intestinal fatty acid-binding protein necrotizing enterocolitis premature preterm urinary intestinal-fatty acid-binding protein Pediatrics RJ1-570 Surgery RD1-811 Amin I E. Shaaban Osama A E. Alfqy Howayda M K. Shaaban Yahya H A. Maqsoud Effat H Assar Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates
description	Introduction: Intestinal fatty acid-binding protein (I-FABP) is located in the apex of mature enterocytes and released into circulation; once the injury of enterocyte happens, its circulating levels are considered an early and sensitive marker of intestinal ischemia as in necrotizing enterocolitis (NEC); because of its small molecular weight, it can be detected in urine. Aims: The aim was to study the usefulness of both serum and urine I-FABP in early diagnosis of NEC and to correlate the serum and urinary levels. Settings and Design: This study was case–control design. Methods: Simultaneous serum and urine samples obtained at the onset of symptoms, in 40 preterms with suspected NEC, with gestational age ± 27.70 weeks and birth weight ± 1.11 kg, i.e., 20 preterms diagnosed at Stage I, 12 preterms at Stage II, and 8 preterms at Stage III, were compared with age- and weight-matched preterms with no NEC. Statistical Analysis: The collected data were tabulated, coded, and then analyzed using the computer program Statistical Package for the Social Science (SPSS version 22). Results: Serum levels of I-FABP in NEC cases were significantly higher than the control group, with a mean of 6005.77 ± 6384.77 and 1480.79 ± 1276.48 pg/ml, respectively (P < 0.001). Urine levels of I-FABP in NEC cases were significantly higher than the control group, with a mean of 5009.22 ± 3941.64 and 2677.62 ± 2257.29 pg/ml, respectively (P = 0.04). Both serum and urine I-FABP levels not only in Stage II are significantly higher than Stage I but also in Stage III are significantly higher than Stage I and II (P < 0.001, P = 0.03, respectively), which showed significant positive correlation with stages of NEC (r = 0.618; P < 0.001; r = 0.306; P = 0.049, respectively). Both serum and urine I-FABP levels had a highly significant positive correlation with each other (r = 0.406 P < 0.0001). Receiving operating characteristic curve showed an area under the curve of 0.92 and 0.81 for serum and urine I-FABP, respectively. Conclusions: Whether serum or urinary I-FABP is valuable in the diagnosis and prediction of NEC and strongly correlated with the disease severity and with each other.
format	article
author	Amin I E. Shaaban Osama A E. Alfqy Howayda M K. Shaaban Yahya H A. Maqsoud Effat H Assar
author_facet	Amin I E. Shaaban Osama A E. Alfqy Howayda M K. Shaaban Yahya H A. Maqsoud Effat H Assar
author_sort	Amin I E. Shaaban
title	Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates
title_short	Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates
title_full	Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates
title_fullStr	Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates
title_full_unstemmed	Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates
title_sort	potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/d4e937e3197b4171ba8459bc8e78b317
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Potential role of serum intestinal fatty acid-binding protein as a marker for early prediction and diagnosis of necrotizing enterocolitis in preterm neonates

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