Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and D...
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2021
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oai:doaj.org-article:d4f26ebf51ac4b15a660e16c376998e22021-11-14T04:28:58ZNon-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity0753-332210.1016/j.biopha.2021.112263https://doaj.org/article/d4f26ebf51ac4b15a660e16c376998e22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010477https://doaj.org/toc/0753-3322The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.Casimiro CárdenasJosé Antonio Torres-VargasAbel Cárdenas-ValdiviaNuria JuradoAna R. QuesadaMelissa García-CaballeroBeatriz Martínez-PovedaMiguel Ángel MedinaElsevierarticleUltra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC–HRMS)Annona muricataGraviolaSoursopAngiogenesisTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112263- (2021) |
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DOAJ |
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EN |
| topic |
Ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC–HRMS) Annona muricata Graviola Soursop Angiogenesis Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
Ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC–HRMS) Annona muricata Graviola Soursop Angiogenesis Therapeutics. Pharmacology RM1-950 Casimiro Cárdenas José Antonio Torres-Vargas Abel Cárdenas-Valdivia Nuria Jurado Ana R. Quesada Melissa García-Caballero Beatriz Martínez-Poveda Miguel Ángel Medina Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity |
| description |
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds. |
| format |
article |
| author |
Casimiro Cárdenas José Antonio Torres-Vargas Abel Cárdenas-Valdivia Nuria Jurado Ana R. Quesada Melissa García-Caballero Beatriz Martínez-Poveda Miguel Ángel Medina |
| author_facet |
Casimiro Cárdenas José Antonio Torres-Vargas Abel Cárdenas-Valdivia Nuria Jurado Ana R. Quesada Melissa García-Caballero Beatriz Martínez-Poveda Miguel Ángel Medina |
| author_sort |
Casimiro Cárdenas |
| title |
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity |
| title_short |
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity |
| title_full |
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity |
| title_fullStr |
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity |
| title_full_unstemmed |
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity |
| title_sort |
non-targeted metabolomics characterization of annona muricata leaf extracts with anti-angiogenic activity |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/d4f26ebf51ac4b15a660e16c376998e2 |
| work_keys_str_mv |
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